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  • 1
    Electronic Resource
    Electronic Resource
    The effect of low and high NaCl diets on oral glucose tolerance (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 724-728 
    Details
    ISSN: 1432-1440
    Keywords: NaCl intake ; Glucose tolerance ; Na+ dependent glucose absorption ; Intracellular Na+ concentration ; Plasma Na+, K+-ATPase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of low and high NaCl diets on plasma glucose and insulin responses to glucose ingestion were investigated in 15 patients with essential hypertension. Oral glucose (75 g) tolerance tests were carried out while patients were taking diets with low (2 g/day) and high (20 g/day) NaCl content. Fasting plasma glucose and insulin levels were both significantly lower during ingestion of the high NaCl diet (p〈0.05). After glucose ingestion, the incremental areas under the two hour plasma glucose and insulin curves were significantly smaller during ingestion of the high NaCl diet (glucosep〈0.005 and insulinp〈0.025). These findings that low NaCl diets increase the glycemic response to glucose loads suggest that use of NaCl restriction for the treatment of essential hypertension may not always be desirable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726415
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Compliance with GLP standards and management in analytical laboratories: current status (1997)
    Springer
    Accreditation and quality assurance 2 (1997), S. 146-149 
    Details
    ISSN: 1432-0517
    Keywords: Key words Analytical laboratories ; Good laboratory practice (GLP) ; Validation ; Good manufacturing practice (GMP) ; Accreditation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  Analytical laboratories in Japan, operating more often as departments within a company than as independent contractors, have to contend with different good laboratory practice (GLP) standards. Problems also occur in the analytical laboratories which must comply with GLP, good manufacturing practice (GMP) and good clinical practice (GCP) regulations within the same facility. The status of these GLP-complied analytical laboratories is reviewed with regard to assurance program, validation method, laboratory information management, and security systems. The differences in the responsible authorities and scopes under the six GLPs are also briefly described. Analytical tests in GLP are not itemized as a test for accreditation. Therefore, the accreditation of analytical laboratories in Japan is currently granted as a part of ISO 9000 approvals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690050120
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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