ISSN:
0736-0266
Schlagwort(e):
Collagen
;
Bone ingrowth
;
Porous coated prostheses
;
Intramedullary bone repair
;
Life and Medical Sciences
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Medizin
Notizen:
A new model was developed to study the histologic and biochemical events during intramedullary bone repair and ingrowth into porous coated implants. Adult chickens were used because of the availability of specific antibody probes. Repair in the metaphysis and diaphysis were compared. Entering through a medial arthrotomy, the distal tibiotarsus was reamed and either impianted with a double-ended porous coated rod or allowed to heal without implantation of a rod. Specimens analyzed histologically at 7, 14, 21, and 70 days postoperatively revealed direct formation of bone by osteoblasts with no evidence of a cartilaginous phase. At 70 days bony ingrowth was observed deep within the porous surface. Analysis of collagens with sodium dodecyl sulfate polyacrylamide gel electrophoresis demonstrated that the synthesis of type I collagen predominated. Biosynthetic data coupled with quantitative immunologic analyses using antibodies to type II and type X collagen showed that neither of these two collagen types, which are characteristic of cartilage undergoing endochondral ossification, were produced during intramedullary bone repair. These results establish that the adult chicken is capable of bony ingrowth into porous coated implants and that this process is through direct bone deposition by osteoblasts without a cartilaginous intermediate.
Zusätzliches Material:
6 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jor.1100070303
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