ISSN:
1432-0533
Keywords:
Spongy degeneration
;
Calves
;
Experimental hyperammonemia
;
Intramyelinic vacuoles
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Experimental reproduction and ultrastructural findings of spongy degeneration of the central nervous system of hyperammonemic calves are described. Hyperammonemia was produced by intravenous infusion of ammonium acetate. Histologic findings were stereotyped in all calves and characterized by widespread vacuolation of white and grey matter of the brain and spinal cord. Electron microscopy revealed widespread intramyelinic vacuoles, some expansion of extracellular spaces and swollen mitochondria. There were minimal changes in neurons, axons and glia, and little evidence of myelin breakdown. Hyperammonemia may be one of the pathogeneses involved in the CNS spongy degeneration in man and domestic animals affected with hepatocerebral diseases and some hereditary disorders.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00703317
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