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  • 1
    Electronic Resource
    Electronic Resource
    Organ distribution of Adriamycin® after intravesical instillation with or without Tween 80 in the rat (1988)
    Springer
    Urological research 16 (1988), S. 325-327 
    Details
    ISSN: 1434-0879
    Keywords: Intravesical chemotherapy ; systemic absorption ; Adriamycin® ; Tween 80
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The absorption of Adriamycin® (ADM) into the systemic circulation and into different organs including the urinary bladder was investigated in the rat after intravesical instillation of ADM with or without a surface active detergent, Tween 80. The postinstillation plasma concentration of ADM increased significantly with increasing dose of the drug. Even though the leakage of ADM into the systemic circulation and into extravesical organs in general was slight a significant increase was observed after addition of Tween 80. The uptake of ADM into the urinary bladder wall was also significantly enhanced by Tween 80 thus the role of this agent in conjunction with intravesical chemotherapy should be further investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263645
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Absorption of Adriamycin® into the systemic circulation after intravesical instillation with or without tween 80 in the rat (1987)
    Springer
    Urological research 15 (1987), S. 21-23 
    Details
    ISSN: 1434-0879
    Keywords: Intravesical chemotherapy ; Systemic absorption ; Adriamycin® ; Tween 80
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The absorption of Adriamycin® (ADM) into the systemic circulation after intravesical administration, using an experimental model in the rat,was closely related to the volume of the instilled solution and the concentration of the drug. The post instillation plasma concentration of ADM was increased after addition of Tween 80 to the instilled solution but the magnitude of the absorption was still discreet and, from a clinical point of view, negligible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256330
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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