ISSN:
1573-8744
Keywords:
clearance curves
;
pharmacokinetics
;
tracer kinetics
;
homogeneous compartments
;
multiexponentials
;
negative powers of time
;
gamma functions
;
random walks with drift
;
distributions of time intervals
;
Inverse Gaussian distributions
;
convolutions
;
models
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract When a clearance curve in pharmacokinetic studies- and in tracer kinetics in general — is well fitted by a sum of negative exponentials of time, in very many cases the data would also be well fitted over much or all of the same period by a function of time consisting mainly of a negative power or by a gamma function. There are also instances where two such power functions can be observed in the same clearance curve. Examples are given from numerous reanalyses of published results. These facts have not been explained, except as being fortuitous, by any existing theory or model based on two or more homogeneous compartments. Theoretical and practical implications are outlined and some general recipes are put forward with a view to replacing multicompartmental analysis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01065658
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