ISSN:
0009-2940
Keywords:
α-Bromoglycine derivatives
;
Amino acids
;
Iron
;
Chromium
;
Tungsten
;
Transition-metal-labeled α-amino acids
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The reactions of protected α-bromoglycine esters R1(O)CNHCH(Br)CO2R2 (R1=Ph, OCMe3; R2 =Me, tBu) with organometallic anions of acetylferrocene, CpFe(CO)(PPh3)-C(O)CH3, (OC)5M=C(OMe)CH3 (M=Cr, W), (OC)3Cr(η6-diphenylmethane), (OC)3Cr[η6-fluorene), (OC)3Cr(η6-dihydroanthracene) and of (OC)3Cr(-η6aniline) and (OC)3Cr(η6-o-toluidine) provide a method for the introduction of organometallic fragments into the side chains of α-amino acids.The complexes may be useful as markers for α-amino acids in peptides.The compound (OC))3Cr(η-o-C6H4(CH3)NHC-(H)(CO2Me)NHC(O)Ph was characterized by X-ray diffraction.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19971300206
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