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  • 1
    ISSN: 1434-9949
    Keywords: Arthritis ; Hepatitis C virus ; Iron overload ; Myalgia ; Phlebotomy ; Rheumatic manifestations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic hepatitis C virus (HCV) infection may lead to many extrahepatic manifestations which pose a serious therapeutic challenge. Recently, increasing evidence suggesting an association between iron overload and chronic HCV infection has emerged. However, the effect of iron reduction therapy on extrahepatic manifestations of HCV infection is unknown. We describe two patients with chronic HCV infection and severe rheumatic manifestations, namely: myalgia and seronegative nonerosive symmetrical polyarthritis. Interestingly, the response to anti-inflammatory and second line drugs was poor but unexpectedly recurrent phlebotomies was followed by marked improvement of the symptoms. This observation suggests that iron overload may have some role in the pathophysiology of HCV associated rheumatic complications. Further studies are needed to confirm our observation and to clarify the underlying mechanism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 14 (1995), S. 580-581 
    ISSN: 1434-9949
    Keywords: Arthritis ; Rickettsia ; Mediterranean Spotted Fever ; Israeli ; Spotted Fever
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Of 15 patients hospitalized because of Israeli spotted fever, 3 developed arthritis during the course of the disease. Treatment with tetracycline was accompanied by full remission of the spotted fever including the arthritis. This suggests that arthritis is not a rare complication of Israeli spotted fever.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Clinical rheumatology 11 (1992), S. 243-247 
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Mud ; Balneotherapy ; Dead Sea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-eight patients with classical or definite rheumatoid arthritis were randomly divided into two groups of fourteen patients each. All patients were treated once a day with mud packs derived from the Dead Sea heated to 40°C and applied over the four extremities, neck and back for 20 minutes. Group 1 was treated with the true mud packs and Group 2 with washed out and less concentrated mud packs. The study was double blind and of two weeks duration. All patients were evaluated by one rheumatologist both before treatment and two weeks later at the end of the treatment period. Follow-up evaluations were made one and three months after conclusion of the treatment. The clinical indices evaluated included duration of morning stiffness, hand-grip strength, activities of daily living, patient's own assessment of disease activity, number of active joints and the Ritchie index. A statistically significant improvement (p〈0.01 or p〈0.05) was observed in Group 1 only in most of the clinical indices, lasting between 1 to 3 months.
    Type of Medium: Electronic Resource
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