ISSN:
1432-2013
Keywords:
Smooth muscle
;
Skinned fibers
;
Ca2+
;
Myosin light chain kinase
;
Contraction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In various skinned smooth muscle fiber preparations, (porcine carotid artery, rat tail artery, chicken gizzard and Taenia coli from guinea pig) a Ca2+-independent myosin light chain kinase (MLCK) initiated a contraction in absence of Ca2+. While the Ca2+ insensitive MLCK was effective on the vertebrate smooth muscles it did not act on the invertebrate skinned skeletal muscle preparation from Limulus and anterior byssus retractor muscle from Mytilus edulis. The results indicate that in vertebrate smooth muscles phosphorylation is sufficient for activation and that there is no obligatory role for an additional mechanism in initiation of contraction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581542
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