ISSN:
1432-1440
Keywords:
Renal failure
;
Ischemia
;
Reperfusion
;
Transplantation
;
Free radicals
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The toxic metabolites of oxygen, including those which are free radicals, have been found to constitute a fundamental common pathway of tissue injury in a wide variety of disease processes, including injury in many organs resulting from post-ischemic reperfusion. Research efforts designed to prevent or ameliorate tissue injury have therefore centered on the pharmacologic inhibition of free radical-mediated mechanisms. This approach has particular application to post-ischemic renal failure seen in renal transplantation, after a well-defined period of graft ischemia, followed by reperfusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01645163
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