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  • 1
    ISSN: 1432-0428
    Keywords: Islet of Langerhans ; insulin secretion ; nitric oxide ; cyclic guanosine monophosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The involvement of nitric oxide as an intracellular messenger in the control of insulin secretion from pancreatic Beta cells was studied in rat islets of Langerhans by measuring: (i) nitric oxide generation in response to physiological insulin secretagogues; (ii) the effects of inhibitors of nitric oxide synthesis on insulin secretory responses to physiological secretagogues, and on insulin synthesis; (iii) changes in islet cyclic guanosine monophosphate in response to secretagogues; (iv) the effects of exogenous cyclic guanosine monophosphate and dibutyryl cyclic guanosine monophosphate on insulin secretion from electrically permeabilised islets and from intact islets, respectively. These studies produced no evidence that nitric oxide generation is required for the initiation of insulin secretion by common secretagogues. However, the results of our experiments suggest that the generation of nitric oxide may be involved in long-term, glucose-dependent increases in cyclic guanosine monophosphate content of islet cells, although the physiological relevance of these changes requires further investigation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cross-cultural gerontology 7 (1992), S. 69-88 
    ISSN: 1573-0719
    Keywords: aging ; cross-cultural ; migration ; modernization ; Polynesia ; Samoa ; status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Ethnic Sciences , Sociology
    Notes: Abstract Samoan cultural values place a high emphasis on respect and obedience toward elders. However, modernization and migration have caused changes in traditional social structure, social organization, household composition, economic opportunities, and health care systems. This article reports results from interviews on attitudes and perceptions of the elderly administered to 137 young adults (aged 18–37) and 106 older adults (aged 41–82) in rural Western Samoa, modernizing American Samoa, and Samoan migrants in urban Honolulu. The results indicate there are significant signs of both change and stability in the status of elderly Samoans. Over 75% of Samoans report that the elderly are respected, obeyed, and consulted on important decisions. However, Samoans in American Samoa and Honolulu report that the status of the elderly has declined over the past ten years. Older Samoans in Honolulu emphasize the maintenance of traditional norms rather than changes in the behavior toward the elderly.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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