ISSN:
1435-1463
Keywords:
Spider toxin
;
JSTX-3
;
convulsion
;
intracerebroventricular injection
;
quisqualate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of a spider toxin (JSTX-3)—a specific blocker of glutamate receptors—on the behavior of mice was studied using an intracerebroventricular (i.c.v.) injection technique. At higher doses (more than 12 nmol/brain), JSTX-3 increased motor activities and induced characteristic symptoms. JSTX-3 at a dose of 4.7 nmol/brain which per se did not produce any abnormal behavior, specifically antagonized quisqualate-induced convulsions but not NMDA- or kainate-induced confulsions. These results indicate that JSTX-3 is a selective antagonist of the quisqualate receptors in the mammalian central nervous system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01257076
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