ISSN:
1435-1463
Keywords:
Spider toxin
;
JSTX-3
;
memory retrieval
;
passive avoidance
;
i.c.v
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of a spider toxin (JSTX-3)—a specific blocker of quisqualate sensitive type of glutamate receptors—on learning and memory was studied in mice using passive avoidance tests (step-through and step-down tests) and the water maze test. JSTX-3 was injected into lateral ventricles of chronically cannulated mice at a dose of 22.2 pmol/brain, which did not produce any apparent behavioral changes. This chemical significantly impaired the retrieval of memory in the step-through test and showed a similar (though not statistically significant) tendency in the step-down test, but it had no effect on acquisition or consolidation of memory in both tests. In the water maze test, this chemical had no effect on escape latencies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01245024
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