ISSN:
1436-2813
Keywords:
Key Words: esophageal carcinoma
;
preoperative chemotherapy
;
biochemical modulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
2 per day, given as a 24-h infusion on days 1–7, and CDDP at a dose of 6 mg/m2 per day, given as a 2-h infusion on days 1–5. Either two or four cycles of chemotherapy were administered to 20 patients with stage III advanced esophageal carcinoma. All 20 patients were then assessed for response and toxicity. An objective response was demonstrated by 11 of the 20 patients, with one complete response (CR) and ten partial responses (PR), bringing the response rate to 55%, with a 95% confidence interval of 27% to 83%. Surgical resection of the tumor was performed in all 20 patients. One patient was found to have a grade 3 histological CR. The median survival of all the patients was 20.5 months, with a range of 4.5 to 48.0 months. Neutropenia and thrombocytopenia developed in five (25%) and two (10%) patients, respectively, and the nonhematologic toxicities were insignificant. The findings of this phase II study indicate that preoperative treatment using 5-FU and low-dose CDDP chemotherapy for patients with advanced esophageal carcinoma appears to achieve a high response rate after short-term administration without affecting the quality of sophisticated lymph node dissection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s005950050367
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