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  • Key words: Langerhans' histiocytosis, Langerhans' cell histiocytosis, bcl-2, proto-oncogene  (1)
  • Photomorphogenesis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Increased endogenous cytokinin in the Arabidopsis amp1 mutant corresponds with de-etiolation responses (1996)
    Springer
    Planta 198 (1996), S. 549-556 
    Details
    ISSN: 1432-2048
    Keywords: Arabidopsis (mutant) ; Cytokinin ; De-etiolation ; Mutant (amp1) ; Photomorphogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The high-cytokinin Arabidopsis thaliana (L.) Heynh. mutant amp1 of has been further characterised. We extend our previous work on the cytokinin level in the amp1 mutant and show that it contains high levels of endogenous cytokinins in both light- and dark-grown plants, and that amp1 can be phenocopied in the dark by growing wild-type plants on exogenous cytokinin. Previously we showed that dark-grown amp1 plants display de-etiolated characteristics such as short unhooked hypocotyls, opened cotyledons and formation of leaves. We further show that amp1 mutants display de-etiolated plastid morphology and increased levels of transcripts of light-regulated genes, indicating that in this mutant light-mediated processes are partially induced in the dark. The amp1 mutant also shows a reduced level of expression of several light-regulated genes compared with the wild type when grown in light, and has an altered dark-adaptation response when compared with the wild type. These results demonstrate an association between high cytokinin levels and de-etiolation, and we infer that cytokinin itself or a cytokinin-mediated process is involved in regulation of etiolation. The map location, phenotypes and de-etiolation responses in the amp1 mutant are different from those of previously described de-etiolated mutants such as det1, det2, cop1 and cop9. We propose a model in which cytokinin acts as a component of the induction of photomorphogenic processes via a signal transduction pathway which is independent of light.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262641
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  • 2
    Electronic Resource
    Electronic Resource
    Bcl-2 Expression in Langerhans' Cell Histiocytosis (1998)
    Springer
    Pediatric and developmental pathology 1 (1998), S. 210-215 
    Details
    ISSN: 1615-5742
    Keywords: Key words: Langerhans' histiocytosis, Langerhans' cell histiocytosis, bcl-2, proto-oncogene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Langerhans' cell histiocytosis (LCH) is an abnormal accumulation of dendritic histiocytes of unknown pathogenesis. It has recently been shown to be a clonal process. Bcl-2 is a proto-oncogene whose protein product is known to inhibit apoptosis. The overexpression of bcl-2 has been demonstrated in a number of neoplasms, presumably prolonging the survival of the neoplastic cells. We examined the expression of bcl-2 in normal Langerhans' cells in the skin and in LCH by immunohistochemistry for protein and in situ hybridization for mRNA to see if it could be implicated in the pathogenesis of this disorder. Additionally, we performed Southern analysis to determine if genomic rearrangement of the bcl-2 gene occurs in cases of LCH. Bcl-2 was not detected in normal skin Langerhans' cells. Eleven of thirteen cases of LCH demonstrated bcl-2 protein expression in the cytoplasm of the Langerhans' cells by immunohistochemistry, while 12 of 13 cases had evidence of bcl-2 mRNA by in situ hybridization. Southern analysis revealed a germline configuration of the bcl-2 gene in the five cases studied. These findings suggest that bcl-2 expression is present and up-regulated in pathologic Langerhans' cells, however, this overexpression does not appear to be due to genomic rearrangement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100249900028
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    Paper (German National Licenses)
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