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  • Key words:Bone mineral density – Hormone replacement therapy – Osteoporosis – Serum lipid profile  (1)
  • Very low density lipoprotein (VLDL) Cholesterol  (1)
  • metoprolol  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    A rapid semi-micro method for the separation of lipoprotein fractions that uses a benchtop ultracentrifuge
    Amsterdam : Elsevier
    Clinica Chimica Acta 226 (1994), S. 95-99 
    Details
    ISSN: 0009-8981
    Keywords: High density lipoprotein (HDL) cholesterol ; Low density lipoprotein (LDL) cholesterol ; Ultracentrifugation ; Very low density lipoprotein (VLDL) Cholesterol
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(94)90107-4
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The influence of beta-adrenoceptor antagonists with and without partial agonist activity on exercise tolerance and muscle lactate production (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 415-417 
    Details
    ISSN: 1432-1041
    Keywords: Epanolol ; metoprolol ; beta adrenoceptor antagonist ; exercise ; lactate ; intrinsic activity ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Epanolol is a beta-adrenoceptor antagonist with partial agonist activity, a property which could be useful in reducing the fatigue associated with beta blockers. In a double-blind, randomized, crossover study we have investigated the effects of metoprolol 100 mg b.d., epanolol 100 mg b.d., and epanolol 200 mg b.d. on blood pressure, heart rate, and exercise-induced fatigue in 10 hypertensive men. Fatigue was measured subjectively by the Borg rating scale and objectively by blood lactate concentrations. Resting and exercise heart rates were lower with metoprolol than with either dose of epanolol. Preexercise standing diastolic blood pressure was lowered by metoprolol, but there were no other treatment effects on blood pressure. Exercise-induced fatigue was not altered by any treatment, whether measured subjectively or objectively. These results do not support the hypothesis that partial agonist activity improves exercise tolerance in hypertensive patients treated with beta-adrenoceptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637640
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Long-Term Effects of Continuous Combined HRT on Bone Turnover and Lipid Metabolism in Postmenopausal Women (1998)
    Springer
    Osteoporosis international 8 (1998), S. 326-332 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bone mineral density – Hormone replacement therapy – Osteoporosis – Serum lipid profile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This study was undertaken to investigate the effect of 10 years of hormone replacement therapy (HRT) on bone turnover and lipid metabolism in postmenopausal women. The single-centre trial was initiated as a 1-year, double-masked, randomized, parallel-group study of continuous combined HRT with 2 mg 17b-estradiol and 1 mg norethisterone acetate administered once daily with or without 1 mg estriol. Following preliminary results which showed no difference between the addition and omission of estriol, patients continued on an open-label extension phase of continuous combined HRT without estriol for a further 9 years. Of the 52 women who entered the original double-masked study, 32 entered the open-label extension phase. The 10-year analysis was based on 27 patients. Major increases in bone mineral density (BMD) of the lumbar spine were seen during the first 3 years of treatment, remaining statistically significant compared with baseline at all visits throughout the 10-year follow-up (p40.025). Statistical modelling confirmed that there were no decreases in BMD after these initial increases. BMD remained 5.5% higher than baseline values after 10 years of continuous combined HRT. Mean total cholesterol levels were significantly reduced after 10 years of therapy (p= 0.012), with no significant changes in serum triglyceride and low-density lipoprotein (LDL)-cholesterol levels from baseline values at this time. High-density lipoprotein (HDL)-cholesterol levels, however, were reduced by 15.4% (p50.001). In conclusion, 10 years of continuous combined HRT resulted in a significant and sustained increase in BMD. This treatment regimen therefore appears to be well suited for the long-term prevention of osteoporosis in postmenopausal women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050071
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    Paper (German National Licenses)
    Fulltext
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