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Digitale Medien

Changes in the cell wall glycoprotein composition of Candida albicans associated to the inhibition of germ tube formation by EDTA (1994)

Gil, M. L. ; Casanova, M. ; Martínez, J. P.

Springer

Archives of microbiology 161 (1994), S. 489-494

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Details

ISSN: 1432-072X

Schlagwort(e): Key words:Candida albicans– Dimorphism – Cell wall – Mannoprotein – EDTA

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract. Hyphal development in Candida albicans was blocked by EDTA. This effect was not due to a general growth inhibition since the chelator did not affect protein and DNA synthesis. Recovery of mycelial growth was observed when EDTA-grown cells were incubated at 37 °C in EDTA-free medium. High-molecular-weight mannoproteins (HMWM) that are mycelium-specific wall components, and particularly a 260-kDa species (HMWM-260), were absent in the wall of cells grown under germination conditions in the presence of EDTA. Synthesis of the HMWM-260 species was not inhibited but its incorporation (secretion) into the wall structure seemed to be blocked in EDTA-treated cells.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00307769

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