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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 67 (1970), S. 218-222 
    ISSN: 1437-1596
    Keywords: Organfixierung ; Tieffrierung des Thorax ; Fixationsmittel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Zur exakten Darstellung der Topographie der intrathorakalen Organe wird die von Kaiserling und Ponfick angewandte Methode der Einfrierung des Thorax durch eine Tiefkühlung bei − 20° C modifiziert. Verglichen mit den gebräuchlichen Methoden der Flüssigkeitsfixation ist die Tiefkühlung sauber und einfach zu handhaben. Die Fixation kann in kurzer Zeit erfolgen. Besonders gut eignet sich dieses Verfahren einmal zur Darstellung traumatischer, zum anderen aber auch chronisch destruierender Veränderungen des Brustraums, da die Retraktion der Lunge vollkommen verhindert wird und somit das pathologisch veränderte Organ in seiner Beziehung zu den Nachbarorganen situsgerecht erfaßt werden kann. Von weiterem Vorteil ist die absolute Farbtreue der Präparate.
    Notes: Summary The precise topography of the intrathoracic organs may be demonstrated by freezing the entire chest, as described by Kaiserling and Ponfick. This method was modified by deep-freezing at − 20° C. By comparison with conventional liquid fixations deep-freezing is clean and simple and can be carried out in a short period of time. This method is particularly advantageous for the demonstration of traumatic changes within the chest as well as for the demonstration of chronic destructive processes. Deep-freezing avoids retraction of the lung, thereby better preserving anatomic relationships. An additional advantage of this method is the preservation of the original colors of the specimen.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0584
    Keywords: Key words AcSDKP ; Hematopoietic stem cells ; Radioprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The tetrapeptide acetyl-N–Ser-Asp-Lys-Pro (AcSDKP) interferes with G1/S-phase progression, and the resulting cell cycle arrest is thought to protect hematopoietic stem cells against injury by cycle-active cytotoxic agents. We investigated the radioprotective effect of AcSDKP in a canine radiation model. Dogs were given total-body irradiation (TBI) at an exposure rate of 10 cGy/min, either without further therapy (control) or with administration of AcSDKP at 0.05–500 μg/kg/24 h beginning before and continuing until after completion of TBI. At 400 cGy of TBI, one of 28 control dogs and one of eight AcSDKP-treated dogs recovered hematopoiesis (p=0.40). At 300 cGy, seven of 21 control dogs recovered hematopoiesis compared with five of five AcSDKP-treated dogs (p=0.01). In dogs given 300 cGy and AcSDKP, the granulocyte nadirs were less profound (p=0.04) and occurred later (p=0.04) than among controls; platelet kinetics did not differ. These data suggest, therefore, that AcSDKP provides a radioprotective effect in dogs exposed to 300 cGy TBI. Such an effect might be beneficial in recipients of intensive radiation therapy. Conceivably, the effect on hematopoietic recovery could be amplified by growth factor administration after irradiation.
    Type of Medium: Electronic Resource
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