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  • Key words Acute renal failure  (1)
  • Mortalität  (1)
  • Ovarian carcinomas  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 257-265 
    ISSN: 1432-1335
    Keywords: CA 19-9/CA 125 ; Pancreatic carcinomas ; Ovarian carcinomas ; Immunohistochemistry ; Radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tumor markers CA 19-9 and CA 125 defined by the monoclonal antibodies 19-9 and OC 125 were investigated with respect to organ specificity and tumor sensitivity. Normal and tumor tissue specimens, and blood samples from 34 patients with pancreatic carcinomas, 40 with ovarian carcinomas and 39 with miscellanous tumors were examined. CA 19-9 and CA 125 were determined by immunohistochemistry (IH) applied to sections of the tumors and adjacent normal tissues. In parallel, the antigens were measured in the patients' sera by radioimmunoassay (RIA). By means of IH CA 19-9 and CA 125 were detected in normal surface cells from many different organs. Both antigens were also found in tissue sections of various types of tumors and in the sera of the corresponding patients. Thus, organ specificity could not be demonstrated. Sensitivity of CA 19-9 was found to be high for pancreatic carcinomas, i.e., 88% of the tumors expressed the antigen shown by IH and 85% of the sera revealed concentrations above the cut-off value (〉37 units/ml). Evidence for CA 125 was high in ovarian carcinomas with a tissue positivity in 83% and elevated (〉35 units/ml) serum levels in 70% of patients. Comparing IH and RIA case by case a discrepancy was found in 14% of cases with positive IH and low serum values a vice versa. Reasons for this finding are small tumor mass not producing elevated serum levels, retention of the antigen inside the tumor cells because of defective release mechanisms demonstrable only by IH, or heterogeneity of tumors with only focal antigen expression not present in the tissue sections investigated and thus disclosable only by RIA. The relevance of immunohistochemical detection of the antigens for therapeutic planning is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensivmedizin und Notfallmedizin 34 (1997), S. 40-45 
    ISSN: 1435-1420
    Keywords: Key words Acute renal failure ; multiple organ dysfunction syndrome ; interhospital transport ; mortality rate ; Schlüsselwörter Akutes Nierenversagen ; Multiorganversagen ; Transport ; Mortalität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Notwendigkeit, auf allen Intensivstationen eine Nierenersatztherapie verfügbar zu haben, steht die Möglichkeit zur Verlegung in spezialisierte Zentren gegenüber. Die vorliegende Studie untersucht die Beeinflussung der Mortalität des Multiorganversagens durch Einführung der Hämofiltration auf dieser Intensivstation gegenüber dem Zwang zur Verlegung in dieser kritischen Phase. Die Daten von 58 Patienten mit akutem Nierenversagen im Rahmen des Multiorganversagens einer anästhesiologisch geleiteten operativen Intensivstation eines kommunalen Krankenhauses wurden retrospektiv ausgewertet. Vor Einführung der Hämofiltration auf dieser Intensivstation im Jahr 1988 mußten 25 Patienten zur Nierenersatztherapie verlegt werden (Gruppe A). Nach 1988 konnten 33 Patienten mit intermittierender veno-venöser Hämofiltration vor Ort behandelt werden (Gruppe B). In Gruppe A war die Mortalität tendenziell höher als in Gruppe B (76% vs 67%). 4 Patienten der Gruppe A verstarben, da für sie trotz Indikation zu einem Nierenersatzverfahren kein Therapieplatz gefunden werden konnte. Bei 3 Patienten gab es zuerst eine Absage, bevor sie dann doch mit Verzögerung in ein anderes Haus verlegt werden konnten; auch diese drei Patienten sind verstorben. Weitere 3 Patienten verstarben innerhalb der ersten 24 Stunden nach Verlegung. Die Indikation zur Nierenersatztherapie im Multiorganversagen war im Untersuchungszeitraum signifikant rückläufig, was auf vielseitige Lerneffekte zurückzuführen ist. Diese Erfahrungen sprechen dafür, in großen Intensivstationen die Möglichkeiten für eine Nierenersatztherapie vor Ort zu schaffen.
    Notes: Summary Renal replacement therapy is of primary importance for the treatment of acute renal failure associated with multiple system organ failure. If renal replacement therapy is not available in the intensive care unit, patients must be transferred to specialized units, where renal replacement therapy can be applied. The present study investigates the mortality of patients in multiple system organ failure with acute renal failure prior and after renal replacement therapy was available in this unit. Data of 58 patients in a multidisciplinary intensive care unit with multiple system organ failure associated with acute renal failure were retrospectively analyzed. Prior to 1988, when hemofiltration was instituted in this unit, 25 patients required an interhospital transmission in order to receive renal replacement therapy (group A). After 1988, 33 patients were treated with intermittent veno-venous hemofiltration in this intensive care unit (group B). Mortality tended to be higher in group A compared to group B (76% vs 67%). In group A four patients died after other units could not admit these patients. Three patients were transferred with considerable delay due to temporary shortage of therapy facilities in other hospitals; these three patients also died. Three patients died within 24 h after interhospital transportation. During the study period the indication for renal replacement therapy in patients with multiple system organ failure decreased, which can be explained with multiple learning effects. Patient groups changed from elderly patients with a lower number of failing organ systems to younger patients with predominantly four failing organ systems. These results favor the provision of renal replacement therapy in every major intensive care unit.
    Type of Medium: Electronic Resource
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