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  • Key words Basic fibroblast growth factor  (1)
  • scallop (Pecten maximus)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Increased expression of basic fibroblast growth factor during chronic rejection in intestinal transplants is associated with macrophage infiltrates (1999)
    Springer
    Transplant international 12 (1999), S. 42-49 
    Details
    ISSN: 1432-2277
    Keywords: Key words Basic fibroblast growth factor ; chronic rejection ; small bowel transplantation ; Small bowel transplantation ; macrophage infiltration ; chronic rejection ; Chronic rejection ; small bowel transplantation ; basic fibroplast growth factor ; Macrophage infiltration ; chronic rejection ; small bowel transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long-term survival of intestinal transplants is hampered by chronic rejection (CR). Since transplants with CR demonstrate fibrotic changes, the cytokine basic fibroblast growth factor (bFGF) may be involved in the tissue remodelling of chronic intestinal rejection. The aim of this study was to investigate the bFGF gene and protein expression and distribution in chronically rejecting intestinal allografts. Orthotopic small bowel transplantation was performed in the allogeneic DA-to-AS rat combination. Cyclosporin was administered temporarily to prevent acute rejection. Controls were DA isografts and normal DA. bFGF gene expression was evaluated using reverse transcriptase polymerase chain reaction (RT-PCR) of the ileum RNA and was standardized against Glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) expression. bFGF protein was determined using immunohistochemistry. To identify the bFGF-positive cell type, sequential sections were stained for cell markers. Allografts showed histological features of CR, whereas isografts preserved normal architecture. bFGF gene expression was present in normal ileum and significantly upregulated in allografts. Immunohistochemical staining showed a significant increase in bFGF protein compared to isografts. Most bFGF-positive cells were localized in the submucosa and muscularis, particularly around the neural plexus. bFGF-positive cells appeared to be ED-2-positive macrophages, strongly suggesting that the site of bFGF production is the activated macrophage. This study demonstrates increased bFGF mRNA and protein in chronically rejecting intestinal allografts that appear to be produced by macrophages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050183
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An Investigation into Behavioural Indicators of Stress in Juvenile Scallops (1999)
    Springer
    Aquaculture international 7 (1999), S. 169-177 
    Details
    ISSN: 1573-143X
    Keywords: behaviour ; recessing ; righting ; scallop (Pecten maximus) ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Recessing and righting behaviour requires a big energetic cost to scallops and if the animals are already weakened by the stress of handling, exposure to air and transport they may find if difficult to carry out these manoeuvres. The objectives of this study were to determine the preferred sediment of scallop (Pecten maximus) spat and to determine the recessing and righting behaviour of spat under a dessication stress. The results showed that the time taken to recess was indirectly proportional to the mean sediment size of the sediment. When using the 'preferred' sediment, recessing and righting speed was indirectly proportional to the degree of exposure to air experienced by the animals. Thus by removing seasonal and size variables we were able to demonstrate a clear relationship between quality and behaviour in juvenile scallops. This test is therefore not only sensitive to changes in spat quality but is also a very quick and simple test to perform.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009291323103
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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