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  • Key words Carmofur  (1)
  • Key words Sugar beet  (1)
  • Keywords: Down regulation; nitric oxide; protein kinase C; subarachnoid haemorrhage; vasospasm.  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Obligatory Roles of Protein Kinase C and Nitric Oxide in the Regulation of Cerebral Vascular Tone: An Implication of a Pathogenesis of Vasospasm After Subarachnoid Haemorrhage (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1063-1068 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Down regulation; nitric oxide; protein kinase C; subarachnoid haemorrhage; vasospasm.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  We previously showed that a canine basilar artery manifested tonic and potent, protein kinase C (PKC)-dependent contractions when nitric oxide (NO) was inhibited. We also reported a linear correlation between chronological changes in the angiographic severity of vasospasm, enhanced PKC, and attenuated guanosine, 13′,15′-cyclic monophosphate (cGMP) activity in a canine subarachnoid haemorrhage model. The activity of cGMP is an indicator of NO-function. Based on this evidence, we have hypothesized that PKC and NO regulate cerebral vascular tone. We particularly focused on the role of NO in a negative feedback mechanism on PKC activity in the maintenance of vascular tone. To further confirm our hypothesis, we investigated the effect of PKC down-regulation on the tonic vascular contraction induced by NO-inhibition.  Canine basilar artery was used in the experiment. Significant down-regulation of PKC activity in vascular smooth muscle cells was obtained by incubation with 10−5 mole/L of phorbol 12-myristate 13-acetate (PMA) for 24 hours. The tonic and potent contraction induced by NO-inhibition was completely suppressed in the PKC down-regulated artery, even though the artery manifested a significant contraction in high-K+ solutions. These results indicate an obligatory role of PKC activity in tonic contraction when NO is inhibited, and support our previous data. Nitric oxide induces vascular relaxation by inhibiting PKC activity. Subarachnoid haemorrhage impairs this inhibition, resulting in PKC-dependent vascular contraction, such as vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050215
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  • 2
    Electronic Resource
    Electronic Resource
    Carmofur-induced leukoencephalopathy: MRI (1995)
    Springer
    Neuroradiology 37 (1995), S. 649-652 
    Details
    ISSN: 1432-1920
    Keywords: Key words Carmofur ; 5-Fluorouracil ; Leukoencephalopathy ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Carmofur, a derivative of 5-fluorouracil, has recently been noted to have an infrequent but serious association with leukoencephalopathy. To our knowledge, there has been no report of early MRI findings in this leukoencephalopathy. We describe a case in which diffuse high signal intensity of the entire cerebral white matter, including the corpus callosum, was seen on T2-weighted magnetic resonance images. Although similar findings can be seen in many other diseases, carmofur-induced leukoencephalopathy should be suspected in a patient treated with carmofur. It is important to know the clinical and MRI characteristics of this condition, for early diagnosis and better prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050170
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Alterations in organization and transcription of the mitochondrial genome of cytoplasmic male sterile sugar beet (Beta vulgaris L.) (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 283-290 
    Details
    ISSN: 1617-4623
    Keywords: Key words Sugar beet ; Cytoplasmic male sterility ; Mitochondrial genome ; Genome rearrangement ; Rf gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have constructed a physical map of the mitochondrial DNA of a cytoplasmic male sterile (CMS) sugar beet line, TK81-MS, and compared it with that published for normal fertile sugar beet (cv. TK81-O) to clarify the differences between the CMS and normal mitochondrial genomes. The TK81-MS genome is present as a single circular molecule of 481.8 kb, or as two molecules of 184.9 and 296.9 kb. The CMS genome was found to be highly rearranged relative to the normal mitochondrial genome, with at least fifteen rearrangement and/or inversion events being required to align the two DNAs. Analysis of transcription patterns of known mitochondrial genes and rearranged regions revealed six genes, coxI, coxII, atpA, atp6, rps3, and orf324, whose expression is altered in the CMS line relative to the normal line. Of these six, only the coxI transcript pattern differs between male-sterile and fertility-restored genotypes, making it likely that the coxI locus is involved in mediating CMS in sugar beet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051085
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    Paper (German National Licenses)
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