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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 3 (1983), S. 221-224 
    ISSN: 1573-7217
    Keywords: Adjuvant therapy ; breast cancer ; ceruloplasmin ; recurrence prediction ; response to therapy ; tumor markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ceruloplasmin (CP), an acute phase reactant, has been found to be elevated in patients with various tumors including breast cancer. We found that the CP level was elevated in 89% of 103 patients with metastatic breast cancer. In 27 patients with measurable metastatic disease that responded to treatment the mean CP level fell by 35% (p〈0.001) and in 22 patients whose disease progressed on treatment, the mean CP level rose by 44% (p〈0.001). Of those patients with Stage II breast cancer that were treated with adjuvant chemotherapy, only 6% of patients with a normal post mastectomy CP level have recurred, whereas 44% of patients with an elevated post mastectomy CP level have recurred (p〈0.01). In following patients with breast cancer, we noted that in those patients that recurred, the CP level became elevated 16–34 weeks prior to any clinical evidence of metastases. We also noted that the CP level became elevated after initially falling in patients receiving adjuvant chemotherapy and on occasion, the initially elevated CP level did not even fall. These circumstances may represent resistant microscopic disease, so that changing to a noncross-resistant chemotherapeutic regimen might be appropriate.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 77 (1998), S. 551-555 
    ISSN: 1439-6327
    Keywords: Key words Oxygen uptake ; Running ; Training ; Fatigue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight male endurance runners [mean ± (SD): age 25 (6) years; height 1.79 (0.06) m; body mass 70.5 (6.0) kg; % body fat 12.5 (3.2); maximal oxygen consumption (V˙O2max 62.9 (1.7) ml · kg−1 · min−1] performed an interval training session, preceded immediately by test 1, followed after 1 h by test 2, and after 72 h by test 3. The training session was six 800-m intervals at 1 km · h−1 below the velocity achieved at V˙O2max with 3 min of recovery between each interval. Tests 1, 2 and 3 were identical, and included collection of expired gas, measurement of ventilatory frequency (f v ), heart rate (f c), rate of perceived exertion (RPE), and blood lactate concentration ([La−]B) during the final 5 min of 15 min of running at 50% of the velocity achieved at V˙O2max (50% −V˙O2max).␣Oxygen uptake (V˙O2), ventilation (V˙ E ), and respiratory exchange ratio (R) were subsequently determined from duplicate expired gas collections. Body mass and plasma volume changes were measured preceding and immediately following the training session, and before tests 1–3. Subjects ingested water immediately following the training session, the volume of which was determined from the loss of body mass during the session. Repeated measures analysis of variance with multiple comparison (Tukey) was used to test differences between results. No significant differences in body mass or plasma volume existed between the three test stages, indicating that the differences recorded for the measured parameters could not be attributed to changes in body mass or plasma volume between tests, and that rehydration after the interval training session was successful. A significant (P 〈 0.05) increase was found from test 1 to test 2 [mean (SD)] for V˙O2 [2.128 (0.147) to 2.200 (0.140) 1 · min−1], f c [125 (17) to 132 (16) beats · min−1], and RPE [9 (2) to 11 (2)]. A significant (P 〈 0.05) decrease was found for submaximal R [0.89 (0.03) to 0.85 (0.04)]. These results suggest that alterations in V˙O2 during moderate-intensity, constant-velocity running do occur following heavy-intensity endurance running training, and that this is due to factors in addition to changed substrate metabolism towards greater fat utilisation, which could explain only 31% of the increase in V˙O2.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 79 (1999), S. 237-243 
    ISSN: 1439-6327
    Keywords: Key words Oxygen uptake ; Running ; Training ; Fatigue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Elevated oxygen uptake (V˙O2) during moderate-intensity running following a bout of interval running training has been studied previously. To further investigate this phenomenon, the V˙O2 response to high-intensity exercise was examined following a bout of interval running. Well-trained endurance runners were split into an experimental group [maximum oxygen uptake, V˙O2 max 4.73 (0.39) l · min−1] and a reliability group [V˙O2 max 4.77 (0.26) l · min−1]. The experimental group completed a training session (4 × 800 m at 1 km · h−1 below speed at V˙O2 max , with 3 min rest between each 800-m interval). Five minutes prior to, and 1 h following the training session, subjects completed 6 min 30 s of constant speed, high-intensity running designed to elicit 40% Δ (where Δ is the difference between V˙O2 at ventilatory threshold and V˙O2 max ; tests 1 and 2, respectively). The slow component of V˙O2 kinetics was quantified as the difference between the V˙O2 at 6 min and the V˙O2 at 3 min of exercise, i.e. ΔV˙O2(63). The ΔV˙O2(63) was the same in two identical conditions in the reliability group [mean (SD): 0.30 (0.10) l · min−1 vs 0.32 (0.13) l · min−1]. In the experimental group, the magnitude of the slow component of V˙O2 kinetics was increased in test 2 compared with test 1 by 24.9% [0.27 (0.14) l · min−1 vs 0.34 (0.08) l · min−1, P 〈 0.05]. The increase in ΔV˙O2(63) in the experimental group was observed in the absence of any significant change in body mass, core temperature or blood lactate concentration, either at the start or end of tests 1 or 2. It is concluded that similar mechanisms may be responsible for the slow component of V˙O2 kinetics and for the fatigue following the training session. It has been suggested previously that this mechanism may be linked primarily to changes within the active limb, with the recruitment of alternative and/or additional less efficient fibres.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Breast cancer research and treatment 17 (1990), S. 3-7 
    ISSN: 1573-7217
    Keywords: cholesterol ; tamoxifen ; adjuvant therapy ; breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The serum cholesterol levels of 123 consecutively and newly diagnosed women with Stage I and II breast cancer taking tamoxifen were compared with a control group of 81 consecutively newly diagnosed women with Stage I and II breast cancer who were not taking a hormonal treatment or supplement. Other factors that were evaluated were age, menopausal status, tumor size, weight, height, Quetelet index, and smoking and alcohol intake history. The mean cholesterol change in patients on tamoxifen (34.2 ± 3.6 mg/dl) was significantly greater than controls (1.0 ± 4.1 mg/dl) (P〈0.001). Serum cholesterol fell by more than 10 mg/dl in 72.9% of women on tamoxifen vs. 35.1% of controls and by more than 40 mg/dl in 39.9% of women on tamoxifen vs. 12.6% of controls. Multivariate analysis revealed that tamoxifen administration (P〈0.0001), initial cholesterol level (P = 0.001), and age (P = 0.04) were significant factors in producing a decrease in serum cholesterol. The administration of tamoxifen as adjuvant therapy to women with newly diagnosed breast cancer resulted in a significant fall in serum cholesterol. This effect of tamoxifen on the serum cholesterol may prove to be an additional benefit in the form of reduced cardiovascular risk in these women.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of behavioral medicine 17 (1994), S. 127-141 
    ISSN: 1573-3521
    Keywords: breast cancer ; adjustment ; cluster analysis ; coping ; fighting spirit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract By means of cluster analytic techniques, four subtypes of psychosocial adjustment were identified in a sample of 122 breast cancer patients who completed the Psychosocial Adjustment to Illness Scale. Internal consistency and internal validity of the derived typology were suggested by the finding that two different hierarchical agglomerative clustering methods (average linkage between groups, Ward's) produced similar solutions. Three of the derived subtypes reported normal affect levels but different patterns of relative strengths and dysfunctions, while the fourth subtype appeared to be highly distressed and globally maladjusted. External validation was demonstrated by differentiating the subtypes on variables of negative affect, avoidance coping, and fighting spirit. The clinical and heuristic implications of these findings are discussed. The findings highlight the need for comprehensive assessment of psychosocial functioning of cancer patients. They demonstrate that even non-emotionally distressed patients can have very different profiles of adjustment and may benefit from correspondingly individually tailored psychosocial interventions.
    Type of Medium: Electronic Resource
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