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  • Keywords: Alzheimer's disease  (1)
  • Neurofibrillary tangles  (1)
  • pyruvate dehydrogenase  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Induction of epitopes associated with neurofibrillary tangles in clonal mouse neuroblastoma (S20Y) cells (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 30-40 
    Details
    ISSN: 1432-0533
    Keywords: Neuroblastoma cultures ; Neurofibrillary tangles ; Paired helical filaments ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Accumulation of paired helical filaments (PHF) in neurofibrillary tangles is a key neuropathological hallmark in Alzheimer's disease (AD). To date, PHF have been found primarily in humans. Cultured murine cholinergic neuroblastoma (S20Y) cells, following exposure to a serum-free medium or a differentiation medium, developed immunoreactivity to anti-PHF antibodies, and to the Alz-50 by immunocytochemical and immunoblot analyses. Electron microscopic examination revealed abundant fascicles of 10-nm filaments coursing tortuously amongst organelles, such as mitochondria, endoplasmic reticulum and dense-core vesicles, in perikarya and in neuritic extensions. However, subcellular structures identical or similar to PHF could not be found in these non-human cells. This convenient cell culture model may prove to be useful for studying certain aspects of the mechanisms underlying the abnormal cytoskeletal alterations which are characteristic of AD and related neurodegenerative disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662635
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Abnormalities of mitochondrial enzymes in Alzheimer disease (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 855-870 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Alzheimer's disease ; mitochondria ; α-ketoglutarate dehydrogenase ; cytochrome oxidase ; pyruvate dehydrogenase ; neurodegenerative disease.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Abundant evidence, including critical information gathered by Prof. Siegfried Hoyer and his colleagues, indicates that abnormalities of cerebral metabolism are common in neurodegenerative diseases, including Alzheimer's Disease (AD). Alterations in mitochondrial enzymes likely underlie these deficits. Replicable reductions in AD brain occur in the pyruvate dehydrogenase complex (the link of glycolysis to the Kreb's cycle), the α-ketoglutarate dehydrogenase complex (KGDHC; the link of Kreb's cycle to glutamate metabolism) and cytochrome oxidase (the link of the Kreb's cycle to oxygen utilization). Available evidence suggests that deficiencies in KGDHC may be genetic in some cases, whereas evidence that the other two enzyme systems have a genetic component is lacking. Additional results indicate that the reductions can also be secondary to other causes including oxidative stress. A variety of data suggest that the mitochondrial insufficiencies contribute significantly to the pathophysiology of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050099
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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