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  • hyperactivity  (2)
  • Keywords: Caspase-1, caspase-3, tumor necrosis factor receptor R1 (p55), Parkinson's disease, brain.  (1)
  • L-dopa  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Rotations induced by L-dopa in parkinsonian rats are reduced by an ingestion of amino acids (1993)
    Springer
    Journal of neural transmission 6 (1993), S. 211-214 
    Details
    ISSN: 1435-1463
    Keywords: Amino acid ; L-dopa ; Parkinson's disease ; rat ; rotation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the effect of amino acid load on L-dopa-induced rotational behavior in rats with unilateral lesion of the nigrostriatal pathway. Pretreatment of rats with an ingestion of high concentration of amino acids significantly reduced the number of rotations induced by subcutaneously injected L-dopa. These results provide the experimental basis for clinical observations that dietary protein affects the response to L-dopa in parkinsonian patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260923
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of three dopamine receptor agonists in MPTP-treated monkeys (1995)
    Springer
    Journal of neural transmission 10 (1995), S. 55-62 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine receptor agonists ; Parkinson's disease ; parkinsonism ; hyperactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behavioral effects of cabergoline, pergolide and bromocriptine were investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys with attention to the induction of hyperactivity, as evidenced by irritability, excitability and aggressiveness. All three drugs improved the parkinsonism in a dose-dependent fashion following a single injection. Among the three dopamine (DA) receptor agonists used, the antiparkinsonian effect of pergolide was the strongest and had an immediate effect, while cabergoline showed the longest duration of the antiparkinsonian effect and was least potent in inducing hyperactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02256629
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Combined effects of cabergoline and L-dopa on parkinsonism in MPTP-treated cynomolgus monkeys (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 1307-1316 
    Details
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; dopamine receptor agonist ; parkinsonism ; hyperactivity ; dyskinesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behavioral effects of L-dopa or cabergoline alone were compared with those of the joint administration of the two drugs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned parkinsonian cynomolgus monkeys with attention to the induction of hyperactivity and dyskinesia. Cabergoline alone at 0.2mg/kg or less improved in a dose-dependent fashion the parkinsonism without inducing hyperactivity and dyskinesia following a single subcutaneous injection. L-dopa alone improved the parkinsonism, but induced hyperactivity and dyskinesia, depending on the dose applied. Doses required for 50% amelioration by L-dopa and cabergoline were 10 and 0.038mg/kg, s.c., respectively. With low doses (50%-amelioration doses), cabergoline or L-dopa alone improved the parkinsonism without induction of hyperactivity and dyskinesia, but the duration of action was brief. Cabergoline in combination with L-dopa was highly effective in improving motor disability without induction of hyperactivity and dyskinesia. Moreover, the duration of action was more prolonged with the coadministration than with the single administration of each drug. These findings suggest that the combined therapy with low doses of L-dopa and cabergoline is beneficial for treating patients with advanced Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271191
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 335-341 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Caspase-1, caspase-3, tumor necrosis factor receptor R1 (p55), Parkinson's disease, brain.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. The activities of caspase-1 and caspase-3 were measured by use of fluoropeptides as substrates for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients. The activities of caspases in the brain were significantly higher in the substantia nigra from parkinsonian patients than those in the brain from control patients (p 〈 0.01). However, the activities of caspases in the caudate nucleus, putamen, cerebellum, and frontal cortex showed no significant difference between parkinsonian and control patients. The tumor necrosis factor (TNF) receptor R1 (TNF-R1, p55) level was also elevated in the substantia nigra of the parkinsonian brain in comparison with that of controls (p 〈 0.05). Since both caspases and TNF-R1 may play important roles in apoptotic cell death through TNF-α-induced signaling pathway, our present data suggest the presence of a proapoptotic environment in the substantia nigra of parkinsonian brain, probably inducing vulnerability of neurons and glias towards a variety of noxious factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050028
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    Paper (German National Licenses)
    Fulltext
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