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  • Keywords: Pramipexole, dopamine, 6-hydroxydopamine, Parkinson, rat, agonist, neuroprotection.  (1)
  • oxidant stress  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 209-228 
    Details
    ISSN: 1435-1463
    Keywords: Pramipexole ; mesencephalic cultures ; levodopa ; toxicity ; pergolide ; bromocriptine ; trophic factor ; oxidant stress ; neuroprotection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The direct-acting dopamine (DA) agonist pramipexole (2 amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrocfiloride) was evaluated for its ability to attenuate levodopa-induced loss of tyrosine hydroxylase immunoreactive (THir, a marker for dopamine neurons) cells in mesencephalic cultures. Pramipexole reduced levodopa-induced THir cell loss in a dosedependent and saturable fashion (ED50=500 pM), its inactive stereoisomer was significantly less potent in this regard and pergolide and bromocriptine had negligible cytoprotective effects. Culture media from mesencephalic cultures incubated with pramipexole for 6 days increased THir cell counts in freshly harvested recipient cultures. The magnitude of this effect was directly proportional to the amount of pramipexole in the donor cultures and heatinactivation of the media abolished the growth promoting effect. The results from this exploratory set of experiments suggest that pramipexole may be cytoprotective to dopamine neurons in tissue culture. Pramipexole's affinity for DA receptors, its antioxidant action or its ability to enhance mesencephalic trophic activity could be responsible for this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01273182
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 159-176 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Pramipexole, dopamine, 6-hydroxydopamine, Parkinson, rat, agonist, neuroprotection.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. The D3 preferring dopamine agonist pramipexole has been shown to attenuate the cell loss induced by levodopa in vitro. Pramipexole was herein evaluated in the 6-hydroxydopamine lesion model to determine its in vivo effect. Rats were treated with pramipexole or saline before and after an intracerebroventricular 6-hydroxydopamine injection. In the preliminary study, 6-hydroxydopamine produced a 68% reduction in striatal dopamine and a 62% loss in tyrosine hydroxylase immunoreactive (THir) cell counts in the substantia nigra. Pramipexole treated animals exhibited a 29% and a 27% reduction in striatal dopamine and THir cell counts, respectively. THir cell counts and striatal dopamine were significantly correlated. In the stereological study, 6-hydroxydopamine reduced THir cell counts by 47% in saline treated animals and 26% in pramipexole treated animals. These data demonstrate that pramipexole attenuates the biochemical and THir cell changes normally produced by 6-hydroxydopamine consistent with its neuroprotective actions in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050014
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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