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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of infusion regimens for thiopentone as a primary anaesthetic agent (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 543-552 
    Details
    ISSN: 1432-1041
    Keywords: thiopentone ; anaesthesia ; intravenous anaesthesia ; multi-stage infusion ; exponential infusions ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Several multi-stage infusion regimens and a computer controlled exponentially decreasing infusion regimen were evaluated in twelve patients undergoing head and neck surgery or neurosurgery. Thiopentone dosage was based on the mean of pharmacokinetic parameter values from the literature and adjusted for each patient's lean body mass in order to rapidly achieve a predetermined plasma thiopentone concentration of 15 or 20 µg/ml in the period following the initial bolus dose to induce anaesthesia. Anaesthesia was satisfactory in all cases. Plasma thiopentone concentrations were maintained between 10–20 µg/ml during infusion in the five patients who received either a four or five stage infusion and in the six patients who received the exponential infusion, but not in the single patient who received a two-stage infusion. The mean recovery time was 111 min. The plasma concentrations of total and unbound thiopentone at awakening showed little intersubject variability, despite considerable differences in total dose and duration of infusion, suggesting the absence of acute tolerance to the drug. Plasma clearance of total thiopentone correlated strongly with calculated lean body mass and to a lesser extent with total body weight suggesting that lean body mass, in particular, should be an accurate predictor of thiopentone maintenance dose requirements. This study shows that it is feasible to use thiopentone as a primary anaesthetic agent during surgery by administering the drug either as an exponentially decreasing infusion or as an infusion comprising 4 or 5 stepwise decreasing rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544065
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of potassium in the soil profile of a sandplain soil under pasture species (1993)
    Springer
    Plant and soil 155-156 (1993), S. 407-410 
    Details
    ISSN: 1573-5036
    Keywords: L. cosentinii ; nutrient recycling ; potassium ; subterranean clover ; wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The influence of pasture species and pasture/crop rotations on the fate of K fertilizer in the soil profile of a sandplain soil was investigated. Results for Lupinus cosentinii, subterranean clover and a subterranean clover/wheat rotation are presented. Potassium was applied as KCl at six rates up to 150 kg K ha-1 for three years; bicarbonate-extractable K was measured at five depths in the profile (0–100 cm) for four years. The net change in available K in the top 100 cm of the profile (kg ha-1) was calculated. There was a gradual increase in K down the profile under all species with fertilizer application. The increase was largest for L. cosentinii, which also appeared to redistribute K from below 100 cm to the soil surface. The K residual value on this soil type was higher than expected with most of the fertilizer applied over three years being retained in the top 100 cm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00025069
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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