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Platelet heterogeneity based on lactic dehydrogenase activity (1992)

Sole, P. ; Zappacosta, B.

Springer

Annals of hematology 65 (1992), S. 135-137

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ISSN: 1432-0584

Keywords: Platelet ; Lactic dehydrogenase

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Mean lactic dehydrogenase (LDH) activity of human platelets is about 5 nU/platelet; expressed on a cell volume basis, it is 0.5 nU/fl. Platelet separation by means of centrifugation on a Percoll discontinuous gradient gives different subpopulations with a clear-cut change of LDH at a mean platelet volume (MPV) of about 6 fl. The LDH content of platelets with a MPV 〉6 fl is constant (about 0.5 nU/fl), while that of small platelets (3〈MPV〈6 fl) is inversely correlated with the MPV and reaches a value of 1.5–2.0 nU/fl. Because small platelets are granule-depleted, we suggest that platelet LDH activity be considered as an in vivo activation index.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01695813

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Effect of adherence to plastic on peripheral blood monocyte and alveolar macrophage chemiluminescence (1993)

de Sole, P. ; Fresu, R. ; Frigieri, L. ; [et al.]

New York : Wiley-Blackwell

Journal of Bioluminescence and Chemiluminescence 8 (1993), S. 153-158

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ISSN: 0884-3996

Keywords: Chemiluminescence ; bronchoalveolar lavage ; alveolar macrophages ; monocytes ; adherence ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology

Notes: The chemiluminescence of peripheral blood monocytes and alveolar macrophages was determined in the presence of luminol and lucigenin, either before or after the cell adherence to the luminometer curvettes. In the case of monocytes, cell adherence induces an increase of luminol-dependent chemiluminescence and has almost no effect on the lucigenin-dependent chemiluminescence. However, it shows a strong inhibition of the lucigenin-dependent chemiluminescence and almost no effect on luminol-dependent chemiluminescence, in the case of alveolar macrophages. These results show that adhesion to plastic alters the metabolic burst of both monocytes and alveolar macrophages. Although the mechanisms are poorly understood, they seem to be related to the modifications that take place during the differentiation of peripheral monocytes to alveolar macrophages.

Additional Material: 5 Ill.