ISSN:
1434-4726
Keywords:
Larynx
;
Squamous cell carcinoma
;
Metastases
;
Tumor markers
;
Cytokeratins
;
Vimentin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The immunohistochemical expression patterns of cytokeratin polypeptides and vimentin were investigated in normal epithelia and squamous cell carcinomas of the larynx with special emphasis on tumor grading. During malignant transformation of epithelial cells, the cytokeratin expresssion patterns changed, depending on the differentiation grade of the carcinomas. In low-grade carcinomas, the expression patterns were close to those of the normal epithelium. With increasing tumor grade, there was decreased expression of stratification cytokeratins and increased expression of basal cell, simple cell and hyperproliferation-related cytokeratins. Increasing tumor grade was also associated with the expression of vimentin, a cytoskeletal protein of mesenchymal cells. No relationship was found between vimentin expression and the presence of lymph-node metastases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01642554
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