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Neutrophilic granulocytosis following lead acetate in female mice (1985)

Hogan, G. R.

Springer

Cellular and molecular life sciences 41 (1985), S. 942-943

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ISSN: 1420-9071

Keywords: Lead toxicity ; neutrophils ; mice

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Lead induces an abrupt neutrophilic granulocytosis with the peak response detected 4 days after treatment. Using the incorporation of tritiated thymidine as an index of neutrophil production, autoradiographic analysis revealed that only about 16% of the total neutrophil increase is associated with a stimulatory effect on production. The remainder of the increase appears to be linked to the panhistotoxic action of lead, promoting migration of neutrophils from reserve sites in the wake of tissue damage.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01970024

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