ISSN:
1432-1041
Keywords:
Lidocaine
;
phenytoin
;
procainamide
;
plasma concentration
;
drug interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effects of phenytoin and procainamide on plasma concentrations of lidocaine have been studied in patients and dogs receiving continuous intravenous infusions of the latter drug. All drugs were given in doses that produced therapeutic plasma concentrations. In the patients, no changes were observed in plasma lidocaine levels after intravenous or intramuscular phenytoin, or after intravenous or oral procainamide. Similarly, in the dogs, intravenous phenytoin had no effect on plasma lidocaine concentrations. However, in both patients and dogs a high incidence of CNS side-effects was recorded during lidocaine — phenytoin combination therapy, which suggests a potential pharmacodynamic interaction between them. The absorption of phenytoin administered intra-muscularly was impaired, probably because of pH-dependent crystallization. This route of administration should be avoided in acute treatment with phenytoin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00560358
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