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  • 1
    Electronic Resource
    Electronic Resource
    Induction of drug metabolizing enzymes by sulfinpyrazone (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 353-358 
    Details
    ISSN: 1432-1041
    Keywords: sulfinpyrazone ; platelet aggregation ; uricosuric action ; enzyme induction ; drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A previous interaction study of sulfinpyrazone (Anturano®) suggested that it induced microsomal drug metabolizing enzymes in the liver. To verify this finding the effect of sulfinpyrazone 800 mg per day for four weeks was investigated in ten healthy volunteers. Both the therapeutic actions of sulfinpyrazone, the uricosuric and the antiaggregating effects, were demonstrated (p〈0.05). The influence on the microsomal drug metabolizing system in the liver was demonstrated by an increase in serum-λ-glutamyl transpeptidase from 15.1 to 23.3 U/l (p〉0.05), a significant increase in the urinary excretion of d-glucaric acid (29.6 to 77.9 µMol/24 h,p〈0.05) and an increase in antipyrine clearance from 50.3 ml/min to 83.9 ml/min (p〈0.05). The possibility of enhancement of drug metabolism during treatment with sulfinpyrazone in combination with other drugs should be kept in mind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544586
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of single and multiple doses of sulphinpyrazone on antipyrine metabolism and urinary excretion of 6-beta-hydroxycortisol (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 797-801 
    Details
    ISSN: 1432-1041
    Keywords: sulphinpyrazone ; drug metabolism ; enzyme induction ; 6-beta-hydroxycortisol antipyrine ; antipyrine metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Sulphinpyrazone decreases the plasma clearance of tolbutamide and S-warfarin and increases the clearance of R-warfarin, theophylline and antipyrine. In order to determine whether sulphinpyrazone is an inducer or inhibitor or both of oxidative drug metabolism, antipyrine and its metabolites as well as 6-beta-hydroxycortisol were measured in urine before, 24 h and after 23 days of chronic administration of sulphinpyrazone (4×200 mg/day). During chronic treatment sulphinpyrazone increased the ratio of 6-beta-hydroxycortisol to the 17-hydroxycorticosteroids by 70% (p〈0.02). The renal clearance of the main oxidative metabolites of antipyrine (4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine) were increased after sulphinpyrazone (p〈0.02). Except for norantipyrine, no change in total excretion of antipyrine and its metabolites occurred after 24 h or after 23 days. It is concluded that sulphinpyrazone induces the enzymes which metabolize antipyrine and cortisol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542523
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrafiltration of enzyme solutions by means of blood dialyzers (1992)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 12 (1992), S. 143-153 
    Details
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Hollow fibres with a symmetrical pore structure as used in artifical kidneys are tested for other purposes. The modules are shown to be suitable for the processing of enzymes such as thermitase, penicillin acylase, uratoxidase, and phosphatase by means of ultrafiltration and diafiltration.These hollow fibre modules are compared with other modules used in laboratory or in small technical devices. Similar values and material transfer coefficients are calculated.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/abio.370120213
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hollow fibre modules as membrane reactor in biocatalysis (1992)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 12 (1992), S. 133-142 
    Details
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: As shown in the case of the enzymatic cleavage of Penicillin G by Penicillin acylase hollow fibre modules of the type MLW (molecular separation value of 10,000 Dalton) produced for blood dialysis are also suitable as membrane reactor.The enzymes physically bound in the hollow fibre allow a reproducible reaction rate and are characterized by an acceptable stability.The studies indicate an operating stability which makes possible low production costs of amino penicillin acid.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/abio.370120212
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    Paper (German National Licenses)
    Fulltext
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