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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 78 (1995), S. 1011-1026 
    ISSN: 1572-9613
    Keywords: Pattern selection ; symmetry breaking ; rigid disks ; close packing ; crystalline order ; point defects ; rattlers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract As a new example of spontaneous pattern formation in many-body systems, we examine the collective means by which a close-packed disk crystal reacts to the presence of a single oversized impurity disk. Computer simulation has been used for this purpose; it creates the jammed impurity-containing packings by a kinetic particle-growth algorithm. Hexagonal primitive cells with periodic boundary conditions were employed, and the “natural” number 3n 2 of disks (including the impurity) ranged upt to 10,800. For impurity diameter 1.2 times that of the other disks, the patterns of observed crystal perturbation displayed several remarkable features. Particle displacements relative to the unperturbed triangular crystal possess local irregularity but long-range coherence. The symmetry of the coherent patterns preserved that of the hexagonal cell for rapid growth, but was lower for slower growth. The final jammed packings contain “rattler” disks of the sort known to apper in random disk packings. Finally, the area increase induced by the presence of a fixed-size impurity appears to grow without bound as the system size (i.e., 3n 2) itself increases.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 60 (1990), S. 561-583 
    ISSN: 1572-9613
    Keywords: Rigid disks ; rigid spheres ; random packings ; rattlers ; grain boundaries ; vacancies ; hexatic phases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Random packings ofN⩽2000 rigid disks in the plane, subject to periodic boundary conditions on a square primitive cell, have been generated by a concurrent construction which treats all disks on an equal footing, as opposed to previously investigated sequential constructions. The particles start with random positions and velocities, and as they move about they grow uniformly in size, from points to jammed disks. The collection of packings displays several striking geometric features. These include (for largeN) typically polycrystalline textures with irregular grain boundaries and linear shear fractures. The packings occasionally contain monovacancies and trapped but unjammed “rattler” disks. The latter appear to be confined to the grain boundaries. The linear shear fractures preserve bond orientational order, but disrupt translational order, within the crystalline grains. A new efficient event-driven simulation algorithm is employed to generate the histories of colliding and jamming disks. On a computer which can process one million floating-point instructions per second the algorithm processes more than one million pairwise collisions per hour.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Periodica mathematica Hungarica 34 (1997), S. 123-142 
    ISSN: 1588-2829
    Keywords: Simulated billiards ; random and tight packings ; polycrystalline ; rattlers ; frustration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Using a computational procedure that imitates tightening of an assembly of billiard balls, we have generated a number of packings of n equal and non-equal disks in regions of various shapes. Our experiments are of three major types. In the first type, the values of n are in thousands, the initial disk configuration is random and a priori one expects the generated packings to be random. In fact, the packings turn out to display non-random geometric patterns and regular features, including polycrystalline textures with "rattlers" typically trapped along the grain boundaries. An experiment of the second type begins with a known or conjectured optimal disk packing configuration, which is then "frustrated" by a small perturbation such as variation of the boundary shape or a relative increase of the size of a selected disk with respect to the sizes of the other disks. We present such frustrated packings for both large n (~ 10, 000) and small n (~ 50 to 200). Motivated by applications in material science and physics, the first and second type of experiments are performed for boundary shapes rarely discussed in the literature on dense packings: torus, a strip cut from a cylinder, a regular hexagon with periodic boundaries. Experiments of the third type involve the shapes popular among mathematicians: circles, squares, and equilateral triangles the boundaries of which are hard reflecting walls. The values of n in these experiments vary from several tens to few hundreds. Here the obtained configurations could be considered as candidates for the densest packings, rather than random ones. Some of these conjecturally optimal packings look regular and the regularity often extends across different values of n. Specifically, as n takes on an increasing sequence of values, n = n(1), n(2), ...n(k), ..., the packings follow a well-defined pattern. This phenomenon is especially striking for packings in equilateral triangles, where (as far as we can tell from our finite computational experiments), not only are there an infinite number of different patterns, each with its own different sequence n(1), n(2), ...n(k), ..., but many of these sequences seem to continue indefinitely. For other shapes, notably squares and circles, the patterns either cease to be optimal or even cease to exist (as packings of non-overlapping disks) above some threshold value n(k0) (depending on the pattern). In these cases, we try to identify the values of n(k0).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 224 (1989), S. 180-188 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Osteocalcin, a major noncollagenous matrix protein of bone, dentin, and cementum, is found in tight association with the calcium phosphate mineral phase of these tissues. This article reviews the structural data for osteocalcin relevant to mineral adsorption. The equilibrium-binding properties for Ca2+ ions and hydroxyapatite are considered, along with the apparent physicochemical effects of osteocalcin on bone mineral dynamics. Several of osteocalcin's possible biological activities (involvement in mineralization, chemoattraction, and leukocyte elastase inhibition) are discussed in relation to the mineral-adsorption characteristics of this protein.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0730-2312
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: A Phase I clinical trial with a bispecific monoclonal antibody (BsAb) (anti HER-2/neu × anti CD 64) is currently being conducted in patients with Stage IV breast carcinoma or Stage III/IV ovarian carcinoma who are refractory to standard therapy and who overexpress the HER-2/neu antigen as determined by immunohistochemistry. The trial is a hybrid Phase Ia/Ib trial in which the principal endpoints are toxicity, determination of the maximum tolerated dose, biological efficacy, and BsAb pharmacokinetics. Clinical efficacy will be assessed employing standard cancer and leukemia group B (CALGB) criteria to categorize tumor responses. The BsAb, designated MDX-210, is a Fab′ × Fab′ construct which is designed to enhance tumor penetration owing to its relatively small molecular size (approximately 100 kD). CD 64 (FcγRI) is a high affinity Fc receptor for IgG and potent cytotoxic trigger molecule for monocytes, macrophages, IFN-γ-activated neutrophils, and G-CSF-activated neutrophils. The anti CD 64 employed in this study is uniquely constructed to bind to an epitope outside the normal ligand binding site and thus should not be blocked in vivo by the relatively high levels of human IgG. Her-2/neu is overexpressed in human bresat carcinomas with poor prognosis. In vitro studies with MDX-210 have shown effective killing of tumor cell lines that express the HER-2/neu antigen. Eight patients have been treated to date. The dosage levels tested to date are 0.35, 1.0, and 3.5 mg/m2 infused intravenously at 6.0 mg/hour. Infusion of MDX-210 has been well-tolerated by all patients. The principal toxicities have been Grade I/II fevers and malaise that have fully resolved by 12 hours post infusion. Evidence of immunological activity has been observed even at the lowest dose tested. Plasma tumor necrosis factor alpha (TNFα) increased to as high as 500 picogram/ml in 5 of 6 patients tested. Peripheral blood monocytopenia, either preceding or concurrent with elevations of plasma TNFα, is consistent with binding of MDX-210 to both immune effector cells and target breast tumor cells. Significant dose-dependent in vivo binding of MDX-210 to CD 64 has been observed for more than 24 hours post infusion. It has been demonstrated in cell culture studies that MDX-210 triggers release of TNFα from immune effector cells in the presence, but not in the absence, of target tumor cells. The observation that MDX-210 is immunologically active at non-toxic doses forms the basis for considering MDX-210 as a candidate chemotherapeutic drug for recurrent or secondary breast cancers.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Specimens of murine yolk sac prepared for light and electron microscopy at 8, 12, and 18 days of gestational age revealed a changing morphology of the endodermal cells in the visceral layer as gestation progressed. Basophilia increased between 8 and 12 days and decreased slightly between 12 and 18 days. These changes corresponded to the development of a highly organized rough-surfaced endoplasmic reticulum by 12 days and its partial replacement by smooth-surfaced elements by 18 days. Staining of frozen sections with tetrazolium dyes revealed a substrate dependent localization of the staining reaction within the cells and suggested an underlying compartmentalization of metabolic activities. Two types of apical granules were observed on the basis of both cytochemistry and electron microscopy. These granules were most numerous at 12 days of gestational age. The observations suggest that although synthesis and absorption doubtless occur simultaneously throughout gestation, the emphasis is on synthesis during the first half of the period and absorption during the second half. It is suggested that the change in fine structure may be due to the rupture of Reichert's membrane and the subsequent establishment of direct contact between the endodermal cells and the uterine wall.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 24 (1922), S. 54-59 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 24 (1922), S. 222-231 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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