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  • 1
    Electronic Resource
    Electronic Resource
    Job-shop scheduling with multi-purpose machines (1990)
    Springer
    Computing 45 (1990), S. 369-375 
    Details
    ISSN: 1436-5057
    Keywords: 90 B 35 ; Job-Shop scheduling ; flexible manufacturing ; shortest path
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Folgende Verallgemeinerung des klassischen Job-Shop Scheduling Problems wird untersucht. Jeder Operation eines Jobs sei eine Menge von Maschinen zugeordnet. Wählt man für jede Operation genau eine Maschine aus dieser Menge aus, so erhält man ein klassisches Job-Shop Problem, dessen minimale Gesamtbearbeitungszeitf(μ) von dieser Zuordnung μ abhängt. Gesucht ist eine Zuordnung μ, dief(μ) minimiert. Für zwei Jobs wird ein polynomialer Algorithmus entwickelt, der dieses Problem löst.
    Notes: Abstract Consider the following generalization of the classical job-shop scheduling problem in which a set of machines is associated with each operation of a job. The operation can be processed on any of the machines in this set. For each assignment μ of operations to machines letP(μ) be the corresponding job-shop problem andf(μ) be the minimum makespan ofP(μ). How to find an assignment which minimizesf(μ)? For problems with two jobs a polynomial algorithm is derived.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238804
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  • 2
    Electronic Resource
    Electronic Resource
    An efficient algorithm for the job-shop problem with two jobs (1988)
    Springer
    Computing 40 (1988), S. 353-359 
    Details
    ISSN: 1436-5057
    Keywords: 90B35 ; Job-shop scheduling ; shortest path
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Es ist bekannt, daß sich Job-Shop-Scheduling-Probleme mit zwei Jobs als kürzeste Wege-Probleme mit Hindernissen darstellen lassen. Gezeigt wird, daß sich ein solches Problem mit einem Aufwand vonO (n logn) auf ein normales kürzestes Wege-ProblemP reduzieren läßt, wennn die Anzahl der Hindernisse ist.P läßt sich überdies mit einem Aufwand vonO (n) lösen.
    Notes: Abstract It is well known that job-shop scheduling problems with two jobs can be formulated as shortest path problems with obstacles in the plane. A reduction of this problem to an unrestricted shortest path problem in a special networkN is constructed inO (n logn) steps wheren is the number of obstacles. The shortest path inN can be found in timeO (n).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02276919
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Monoclonal antibody AG7 inhibits fertilization post sperm-zona binding (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 33 (1992), S. 451-462 
    Details
    ISSN: 1040-452X
    Keywords: Sperm antigens ; Acrosome reaction ; Calcium influx ; Zona pellucida ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Monoclonal antibodies (mAbs) against sperm cells are currently being used in an effort to define spermatozoal antigens involved in the fertilization process. We have produced a number of anti-human sperm mAbs by immunization of female mice with the 100,000 × g supernatant of octylglycoside-solubilized washed human sperm. From a panel of mAbs, 1 antibody, AG7, was selected and characterized due to its fertilization-inhibiting characteristics. MAb AG7 defines a sperm acrosome antigen-1 (SAA-1) located in the acrosomal region of human sperm as evaluated by indirect immunofluorescence. Staining of life sperm cells indicated that the antigen is present on the sperm surface. SAA-1 was also found on sperm of several other mammalian species, implying evolutionary conservation of the antigen. SAA-1 was first observed on testicular sperm and can be followed through epididymal transit, ejaculation, and capacitation. When applied in a mouse in vitro fertilization assay, mAb AG7 inhibits fertilization by greater than 95%, and inhibition is dose dependent, with half-maximal inhibition at 0.8 μg/ml. The block to fertilization could not be attributed to sperm agglutination, inhibition of motility, interference with adhesion to the zona pellucida, or inhibition of fusion with the oocyte membrane. MAb AG7 was demonstrated to inhibit calcium influx in spermatozoa in vitro (measured using the fluorescent indicator fura 2), a prerequisite for the acrosome reaction. Initial biochemical characterization of the antigen suggests it is proteinlike in nature, with a molecular weight of approximately 220 kD. The results suggest that SAA-1, identified by mAb AG7, is a sperm antigen crucially involved in the fertilization process, possibly an atypical steriod receptor or ion channel located within the sperm plasma membrane. © 1992 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080330412
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  • 4
    Electronic Resource
    Electronic Resource
    Transforming growth factor-alpha augments meiotic maturation of cumulus cell-enclosed mouse oocytes (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 28 (1991), S. 94-98 
    Details
    ISSN: 1040-452X
    Keywords: Oocyte maturation ; Germinal vesicle breakdown ; Meiotic inhibitor ; In vitro ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Growth factors have been shown to play an important role in the regulation of ovarian function. In this study, we examined the effects of transforming growth factor-α (TGF-α) on the meiotic maturation of immature mouse oocytes in vitro. Cumulus cell-enclosed oocytes were exposed to TGF-α with or without the meiotic inhibitor hypoxanthine (HX), and oocyte maturation was assessed by germinal vesicle breakdown (GVBD). Likewise, mechanically denucded oocytes were examined for GVBD following exposure to HX and TGF-α. When cumulus cell-enclosed oocytes were exposed to TGF-α (1 μg/ml) in the presence of HX (4 mM), an increrase in GVBD was observed first after 5 hours of culture. Maximal stimulation was reached at 24 hours when 70% of the oocytes underwent maturation in the presence of TGF-α and HX as compared to 33% with HX only. Concentrations of TGF-α as low as 0.1 ng/ml produced a similar stimulatory response after 24 hours of culture. Spontaneous maturation in the presence of TGF-α, but without HX, was also enhanced. The stimulation of GVBD by TGF-α showed an increase over time both with and without HX. When denuded oocytes were exposed to TGF-α in the presence of HX, no effect was observed. Our results suggest that TGF-α is a potent stimulator of mouse oocyte maturation in vitro and that is effect is mediated by the surrounding cumulus cells. In view of the established presence and action of TGF-α in the intact ovary, these studies indicate that TGF-α may be part of an intricate system regulating the latter stages of maturation of oocytes during follicular development in vivo.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080280115
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    Paper (German National Licenses)
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