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  • 1
    Electronic Resource
    Electronic Resource
    Fine structure of the alveolar macrophage of the cat and modifications of its cytoplasmic components during phagocytosis (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 167 (1970), S. 277-289 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The alveolar macrophage of the cat shares some features with the alveolar macrophages of ordinary laboratory mammals and man, mainly a voluminous Golgi zone exhibiting evidence of secretory activity. The very numerous typical lysosomes appear to be a secretory end product. They increase in size by a fusion process. At some stage of this process dense periodic structures, crystal-like, become visible in intermediate size lysosomes, which later form heterogeneous crystal-like granules characteristic of the cat's alveolar macrophage.The crystal-like granules are bounded by a unit-membrane pattern and contain a dense periodic parallel lamellar material (crystal-like) mixed with fluffy amorphous substance and surrounded by a clear homogeneous material. Based on its structure as observed at a high magnification, and its behavior during phagocytosis, this crystal-like material appears to be composed of lipid.Intra-pulmonary injection of red blood cells was carried out in order to observe the fate of the crystal-like granules during phagocytosis as compared to that of typical lysosomes. Like typical lysosomes the crystal-like granules become reduced in number and undergo incorporation to the phagocytic vacuoles, demonstrating their lysosomal nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091670303
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  • 2
    Electronic Resource
    Electronic Resource
    Fine structure of myogenesis and elastogenesis in the developing rat lungThis work has been supported by the Medical Research Council of Canada (Grant ME 3388). (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 179 (1974), S. 343-359 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The processes of myogenesis and elastogenesis are studied under the electron microscope in developing rat lungs, throughout the 15th to the 21st days of the gestation period. Myogenesis follows bronchial development and stops at the beginning of the alveolar zone, at the primitive respiratory bronchiole level. Elastogenesis appears at the periphery of the myoblasts during their differentiation. Thin myofilaments only are observed within myoblasts and their formation precedes that of dense bodies.Primitive respiratory bronchioles are visible on the 19th day and are characterized by an early elastogenesis carried out by fibroblasts. At this stage there are no elastic fibers around the alveolar tubules. Then (20th and 21st days) elastogenesis spreads throughout the alveolar zone, accompanying the alveolization process. Peculiar morphological characteristics of the pulmonary fibroblast are underlined. In relation to both muscular cells and fibroblasts the fine structural features of the rat pulmonary elastogenesis are identical to those previously described in other organs. Myoblasts and fibroblasts probably originate from the same primitive mesenchymal cell. Their differentiation depends on the zone where they are located. The relations between connective tissue and epithelial cell differentiation suggest a control of lung development by means of reciprocal induction processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091790306
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  • 3
    Electronic Resource
    Electronic Resource
    Morphological aspects of type II alveolar pneumocytes following treatment with puromycin in vivoPart of these results was presented at the 87th Session of the American Association of Anatomists (Cleveland, Ohio, April 1st to 4th, 1974). (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 148 (1977), S. 275-293 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Ultrastructural modifications of type II pneumocytes (PNM-II) in mice were analysed 125 and 155 minutes after puromycin treatment (12 mg/100 gm at 0, 30, 60 and 90 minutes). A quantitative evaluation of the cell compartments was carried out and the inhibition of protein synthesis in PNM-II was monitored by light microscopic radioautography, following 3H-leucine injection.In electron micrographs, following a 125-minute puromycin treatment, the number and size of lamellar bodies, the precursors of lung surfactant material, appeared markedly reduced. The multivesicular bodies (MVB), which are normally very frequent in PNM-II, had almost completely disappeared, as had composite bodies. Golgi saccules were dilated, while the area occupied by Golgi vesicles was enlarged. Observations following the 155-minute puromycin treatment showed a strong enhancement of these modifications. Smooth and coated vesicles of the Golgi area, as well as peroxisomes, did not appear modified by puromycin. Elongated zones of autophagy were more prevalent after 125-minute treatment than after the 155-minute one.Small bodies were frequently observed in the cytoplasm, near the Golgi zone. They were bounded by a smooth membrane and contained tiny vesicles and/or electron-dense lamellae similar to those present within the lamellar bodies. Parallel membranes formed folds, some of them in continuity with lamellar bodies, thus encircling portions of cytoplasm. These structures, which were few in number in controls, were very frequently observed in treated cells, mainly after the 125-minute treatment.These extensive alterations of PNM-II morphology appeared to be related to a disturbed production of pulmonary surfactant.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001480206
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  • 4
    Electronic Resource
    Electronic Resource
    In vivo differentiation of brown adipocytes in adult mice: An electron microscopic study (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 188 (1990), S. 366-372 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The differentiation of brown adipocyte precursor cells was studied in interscapular brown adipose tissue of adult mice by electron microscopy. Different stages of cell differentiation were characterized in situ. Previous autoradiographic studies suggested that interstitial cells represent the precursor cells of fully differentiated brown adipocytes. The present observations provide morphological evidence for a progressive differentiation of interstitial stem cells into mature brown adipocytes. Four typical stages of development were identified: (1) interstitial cells, (2) protoadipocytes, (3) preadipocytes, and (4) mature brown adipocytes. Interstitial stem cells were small spindle shaped cells, situated between brown adipocytes and characterized by a high nuclear-cytoplasmic ratio, the scarcity of organelles, and the absence of lipid inclusions. Protoadipocytes resembled interstitial cells except that they contained a few tiny lipid droplets in their cytoplasm. Preadipocytes had a larger cytoplasm enclosing many mitochondria and lipid droplets; the smooth endoplasmic reticulum was well developed surrounding the lipid droplets, and was closely associated with the mitochondria. Preadipocytes had the typical structure of growing cells, developing long cytoplasmic processes between and around blood capillaries. Mature brown adipocytes represented the final stage of differentiation. Almost all their cellular volume was occupied by lipid droplets and numerous mitochondria with very dense cristae. Brown adipocytes were also characterized by a tight association with blood capillaries, as expected from metabolically active cells requiring oxygen and substrates. These observations provide direct ultrastructural evidence for a progressive differentiation of interstitial cells into brown adipocytes with a continuum of intermediate cellular types.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001880404
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