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  • 1
    Electronic Resource
    Electronic Resource
    The in vitro effect of gold complexes on bone resorption (1986)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 4 (1986), S. 188-193 
    Details
    ISSN: 0736-0266
    Keywords: Bone resorption ; Gold complexes ; Lysosomal enzymes ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Mouse calvaria were maintained in organ culture without serum additives. The effects of three gold complexes - aurothioglucose, aurothiomalate, and auranofin - on active bone resorption (45Ca release) and hydroxyproline synthesis were determined. The influence of these compounds on DNA and protein synthesis and lysosomal enzyme release from calvaria was also assessed. All gold complexes reduced bone resorption to some extent, with auranofin being the most potent within a narrow concentration range (10-6 M). This concentration of auranofin also significantly inhibited collagen synthesis, although DNA and protein synthesis were unaffected. None of the compounds tested appeared to mediate their action via significant inhibition of lysosmal enzyme release.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100040207
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The evaluation of bone remodeling about orthopaedic implants with ultrasound (1989)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 7 (1989), S. 607-611 
    Details
    ISSN: 0736-0266
    Keywords: Total hip arthroplasty ; Bone remodeling ; Ultrasound ; Elastic stiffnesses ; Scanning acoustic microscopy ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Total hip arthroplasty causes biomechanical changes in the normal femur, including a redistribution and concentration of stress. These mechanical alterations in the femur cause local remodeling and resorption that affect the geometry and mechanical properties of the bone. Two complementary ultrasonic techniques were used to study the local adaptive remodeling of bone due to prosthesis implantation. An ultrasonic wave propagation technique was used to determine elastic properties and a new scanning acoustic microscope (SAM) mapped the acoustic impedance profile of each section. The effects of the implantation of two types of hip prostheses, an uncemented bipolar prosthesis with an Austin-Moore type stem and a cemented Charnley prosthesis, were investigated. Both prostheses had a detrimental effect on local elastic properties as determined by acoustic velocity measurements. The SAM system provided information about local inhomogeneities in bone properties not obtainable by any other means. The acoustic impedance maps highlighted bone resorption and bone remodeling on a microstructural level.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100070420
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A reflection scanning acoustic microscope for bone and bone-biomaterials interface studies (1988)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 6 (1988), S. 770-775 
    Details
    ISSN: 0736-0266
    Keywords: Scanning acoustic microscopy ; Acoustic impedance mapping ; Bone-implant interface ; Bone micromechanics ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A relatively simple scanning acoustic microscope (SAM) that operates in the reflection mode has been constructed. The system uses a 20 MHz spherically focused transducer, acting both as transmitter and as detector, to obtain acoustic impedance information on a thin surface layer at a maximum resolution of approximately 100 μm. The specimen is mounted on an X-Y driving system (precision, 5 μm) under computer control in order to scan a grid of 256 × 256 points across areas ranging from 6.5 to 1300 mm2. An algorithm is used to reference the data against standards; specially developed software provides for pseudo-color mapping, three-dimensional images, zooming to 16X magnification, contouring, and single line profiles of the data. The system has been used to determine inhomogeneities in surface acoustic properties of mineralized tissues and implant materials, in many cases as a complement to using ultrasonic wave propagation techniques to measure the bulk anisotropic properties.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100060521
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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