ISSN:
1432-198X
Keywords:
Key words Neoral
;
AUC
;
Pharmacokinetics
;
Limited sampling strategy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The improved pharmacokinetics of Neoral allows the development of an accurate estimate of the full area under the concentration time curve (AUC) from a limited sampling strategy. As no such strategy has been derived from pharmacokinetic data obtained from children on 12-hourly dosing, and as patient convenience demands shorter sampling times, we derived a limited sampling strategy from 45 AUCs obtained from 19 pediatric renal transplant patients by stepwise forward multiple regression, and prospectively tested them on a separate group of 49 AUCs obtained from 18 pediatric renal transplant patients. Full cyclosporine (CsA) AUCs were obtained from samples drawn pre dose (C0) and at 2, 4, 6, 8 and 12 h post dose (C2, C4, C6, C8, and C12). High-precision predictions of full AUC were obtained based on the formula: AUC = 444 + 3.69 × C0 + 1.77 × C2 + 4.1 × C4 (mean prediction error ± SD = 0.3 ± 6.4%, 95% confidence interval=–1.7% to 1.9%.) In conclusion, CsA exposure in pediatric renal transplant patients on 12-hourly Neoral dosing can be reliably predicted by an early time point-based limited sampling strategy in children. This formula has the advantage of obtaining trough as well as AUC from one brief, convenient sampling period.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004670050691
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