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  • 1
    Electronic Resource
    Electronic Resource
    Radioprotective effects of the immunostimulating lauroylpeptide LtriP (RP 56142) (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 160-166 
    Details
    ISSN: 1420-9071
    Keywords: Lipopeptides ; immunostimulation ; irradiation ; M-CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The lipopeptide lauroyl-L-Ala-γ-D-Glu-L,L-A2pm (LtriP) increased the resistance of mice to the lethal effect of γ-ray irradiation. The radioprotective effect was dependent on the doses of LtriP and of radiation. Maximum survival was observed when the lipopeptide was injected on two successive days before irradiation. This activity seems to be related to immunostimulating functions, since the non-immunostimulating analog lauroyl-L-Ala-γ-D-Glu-D,D-A2pm-Gly, containing D,D-diaminopimelic acid, was not radioprotective. The protective activity might result from an induction of cytokines, such as IL-1, TNF and M-CSF, since LtriP induced the mRNA expression and the secretion of these immunomodulators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01989422
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 882-886 
    Details
    ISSN: 1420-9071
    Keywords: Lipopeptides ; immunomodulation ; cytochrome P-450 ; lipid peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunomodulating lipopeptides lauroyl-L-Ala-γ-D-Glu-LL-A2pmNH2-Gly (RP 44.102) and lauroyl-L-Ala-γ-D-Glu-LL-A2pmNH2 (RP 56.142) were found to protect mice against the hepatotoxicity of paracetamol, which is due to cytochrome P-450 dependent formation of toxic metabolites and radicals. In fact they decreased the amount of hepatic microsomal cytochrome P-450, and the level of CCl4-induced lipid peroxidation. In contrast lauroyl-L-Ala-γ-D-Glu-DD-A2pmNH2 (RP 53.204), which only differs by the configuration of the two chiral carbons of A2pm (diaminopimelic acid) and is not an immunomodulating agent, failed to protect against poisoning by paracetamol and had no effect on the level of hepatic cytochrome P-450 or the microsomal CCl4-induced lipid peroxidation. This provides a clear connection between the immunostimulating properties of a compound and its effects on xenobiotic biotransformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954064
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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