ISSN:
1432-2072
Keywords:
Lithium
;
Myo-inositol
;
l-Chiro-inositol
;
Pilocarpine
;
Lithium-pilocarpine seizures
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed bymyo-inositol, rats were pretreated with intracerebroventricular (ICV) injections ofmyo-inositol, artificial CSF orl-chiro-inositol. Lithium chloride, 3 meq/kg was administered intraperitoneally 20–24 h prior to the subcutaneous injection of pilocarpine 20 or 30 mg/kg. In both experiments,myo-inositol significantly prolonged the latency to the appearance of clonic seizures and lowered the pilocarpine seizure score.myo-Inositol prevented the development of clonic seizures in 50% of the rats receiving pilocarpine, 20 mg/kg. The levels of corticalmyo-inositol in rats injected withmyo-inositol were approximately double those of the CSF andl-chiro-inositol groups.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02246978
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