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  • Lungenmetastasen  (1)
  • Prophylaxis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Transplant international 11 (1998), S. S499 
    ISSN: 1432-2277
    Keywords: Key words Ganciclovir ; Prophylaxis ; CMV infection ; Lung transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cytomegalovirus (CMV) infection causes both acute and chronic allograft damage. The aim of this study was to analyze the utility of ganciclovir in preventing CMV infection in pulmonary allografts. Thirty five consecutive lung (LTX) and heart–lung (HLTX) transplant patients were studied from 1990 to 1996. CMV prophylaxis was started in January 1995. Recipients with CMV-positive serology received ganciclovir on postoperative days (POD) 7–28. Acyclovir was given on POD 29–90. Recipients with CMV-negative serology received ganciclovir on POD 7–90 if the serology of the donor was positive. CMV was demonstrated by rapid cell vial culture and/or detecting CMV-specific antigens in bronchoalveolar lavage (BAL) samples. The time point of the first BAL fluid specimen exhibiting CMV was estimated using the Life Table method. BAL samples of all the recipients without ganciclovir treatment became positive for CMV, whereas two of the 11 patients with ganciclovir administration remained negative. Ganciclovir significantly (P 〈 0.05) delayed but did not absolutely prevent CMV infection after LTX and HLTX.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 727-727 
    ISSN: 1435-2451
    Keywords: Pulmonary metastases ; Operative treatment ; Lungenmetastasen ; Operative Behandlung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Insgesamt 59 Patienten wurden wegen Lungenmetastasen extrapulmonaler Malignome in den Jahren 1955–77 operativ behandelt. Die Überlebensrate war 15%/5 Jahre im ganzen Krankengut und 32%/5 Jahre für die Fälle von 1972–77. Die 5-Jahres-Prognose für die Fälle mit solitären Metastasen war 20%, mit multiplen Metastasen 11%, für die mit freiem Intervall weniger als ein Jahr von der Primäroperation 8% und 30% für die mit freiem Intervall mehr als drei Jahre. Die Prognose der Osteosarkome war nicht schlechter als diejenige der Hypernephrome.
    Notes: Summary A total of 59 patients with hematogenous pulmonary metastases were operated in 1955–1977. The 5-year survival rate was 15% for the whole series and 32% for the patients treated in 1972–1977. The 5-year prognosis was 20% in solitary metastases and 11% in multiple metastases. In cases with a disease-free interval of less than 1 year after the primary operation, the 5-year prognosis was 8 %. When the disease-free interval was more than 3 years, the 5-year prognosis was 30%. The prognosis of osteosarcomas did not differ from that of hypernephromas.
    Type of Medium: Electronic Resource
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