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  • 1
    ISSN: 1432-1459
    Keywords: Meningopolyneuritis Garin-Bujadoux-Bannwarth ; Lyme disease ; Oligoclonal bands ; Antibody specificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The specificity of immunoglobulin (Ig) for components of Borrelia burgdorferi was investigated in cerebrospinal fluid (CSF), serum and in CSF oligoclonal bands from nine patients with meningopolyneuritis Garin-Bujadoux-Bannwarth (MPN-GBB). All patients showed specific IgG and IgM antibodies in serum and CSF when incubated with a lysate of B. burgdorferi strain B 31. Specific antibody was detected in CSF but not in paired serum samples, indicating intrathecal synthesis. Investigation of the specificity of oligoclonal Ig in the CSF revealed oligoclonal bands with specificity for B. burgdorferi in one of the nine patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1590-3478
    Keywords: Lyme disease ; neuroborreliosis ; vasculitis ; vasculitic mononeuritis multiplex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La borreliosi di Lyme è una malattia infettiva causata dalla spirochete Borrelia burgdorferi. Le complicanze neurologiche sono segnalate con frequenza, ma la loro patogenesi rimane oscura. Noi presentiamo il caso di un paziente con positività di anticorpi al test ELISA e con studio istologico e di immunofluorescenza di una biopsia del nervo periferico che comprova l'esistenza di una neuropatia vasculitica.
    Notes: Abstract Lyme borreliosis is an infectious disease caused by the spirochete Borrelia burgdorferi. Neurological complications are frequently reported but the pathogenesis remains largely unknown. We report on a patient with positive borrelia antibodies at ELISA and immunoblotting and with histological and immunofluorescence study of peripheral nerve biopsy consistent with vasculitic neuropathy.
    Type of Medium: Electronic Resource
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