ISSN:
1432-2307
Keywords:
Hepatic marginal zone B-cell lymphoma
;
Mantle cell lymphoma
;
MALT lymphoma
;
Leu-1(CD5)
;
Surface IgD
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We report a rare case of primary hepatic lymphoma, Stage II disease, in a 48-year-old male who had a solitary hepatic tumour measuring 4×4.5×3 cm. The tumour showed a nodular growth pattern and lymphoepithelial lesions with bile ducts. Some neoplastic nodules had a non-neoplastic atrophic germinal centre and/or a thin mantle cell layer. Morphologically, the neoplastic cells were centrocyte-like cells or intermediate lymphocytes. They expressed L26(CD20)+/LN-1(CDw75)±/LN-2(CD74)+/cyclin D1− and had a monotypic immunoglobulin of cytoplasmic IgM (к) on paraffin sections. The neoplastic cells or neoplastic nodules expressed surface IgM+/surface IgD±/Leu-1(CD5)+/DRC-1+/alkaline phosphatase+/B1(CD20)+/B4(CD19)− on fresh frozen sections. We therefore diagnosed this case as primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype. We confirm that it is difficult to differentiate extranodal marginal zone B-cell lymphoma (low grade B-cell lymphoma of mucosa-associated lymphoid tissue type; MALT lymphoma) and mantle cell lymphoma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00196707
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