ISSN:
1432-2072
Keywords:
Tele-methylhistamine
;
MAO B
;
Deprenyl
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Tele-methylhistamine, the first metabolite of histamine in tissues which lack diamine oxidase, is shown to be a substrate for human MAO B. Human liver homogenates were incubated with 3H-tele-methylhistamine and the products separated using thinlayer chromatography. The major product was 3-methylimidazoleacetic acid, the oxidatively deaminated metabolite of tele-methylhistamine. The reaction was inhibited by low concentrations of (-)deprenyl, the specific MAO B inhibitor. Tele-methylhistamine was also found to inhibit competitively the oxidation of phenylethylamine, but not that of 5-hydroxytryptamine, providing further evidence that it is oxidized by MAO B itself and not a related enzyme. This finding implies that (-)deprenyl and other MAO inhibitors used clinically may interfere with histamine metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433097
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