ISSN:
1432-2072
Keywords:
Horizontal Stereotypy
;
Vertical Stereotypy
;
d- and l-Amphetamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Behavioural effects in the Open Field test following the administration of d- and l-amphetamine were compared in rats. A significant difference was found between the effects of the two isomers on horizontal activity, d-amphetamine alone causing horizontal stereotypy. In both cases dose-response relations were curvilinear. On the other hand, although both isomers produced vertical stereotypy, the dose-response relations were generally monotonic increasing with no signifiacnt differences between isomers. These differential effects on behaviour have been explained on the basis of stereospecificity of adrenergic neurons for amphetamine. The results of the study are consistent with earlier hypotheses that the horizontal and vertical stereotyped behaviours of rats in the Open Field situation are functions of brain noradrenergic and dopaminergic systems, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421459
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