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  • 1
    Electronic Resource
    Electronic Resource
    On the relationship between l-DOPA therapy and CSF monoamine metabolites in parkinson's disease (1973)
    Springer
    Journal of neurology 204 (1973), S. 149-154 
    Details
    ISSN: 1432-1459
    Keywords: l-DOPA treatment ; Monoamine metabolites in CSF ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HVA, the main dopamine catabolite, was shown to be decreased in CSF of parkinsonian patients. A significant relationship was also shown between clinical improvement and HVA concentration increase in CSF. It was, however, recently claimed that such increase was not specific. A study on the CSF concentrations of HVA and 5-HIAA (the main serotonin metabolite) was undertaken on 10 parkinsonian patients. The determinations were made before and after l-DOPA therapy, when a satisfactory clinical status was achieved. The results obtained clearly demonstrate that a large increase of HVA was found in CSF during l-DOPA therapy, but no relationship was found between HVA levels and clinical improvement. A decrease of 5-HIAA in CSF during l-DOPA treatment was found. These results are discussed in the light of a relationship between dopamine and serotonin during l-DOPA therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315939
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on low-level MDR cells (1993)
    Springer
    Cytotechnology 12 (1993), S. 257-264 
    Details
    ISSN: 1573-0778
    Keywords: low resistance ; MDR ; P-glycoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Acquired or spontaneous resistance is a major clinical problem in the treatment of cancer. Low levels of MDR gene expression or P-glycoprotein have been correlated with a high level of drug resistance in vitro and a poor response to chemotherapy in some tumors. A strong correlation between MDR mRNA, P-glycoprotein levels and degree of drug resistance has not been found in several resistant model tumor cell lines. In some cell lines at low and high level of resistance different mechanisms seem to be involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00744667
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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