ISSN:
1435-1463
Keywords:
MPTP
;
MPDP+
;
MPP+
;
substantia nigra
;
nigrostriatal neurons
;
neurotoxin
;
dopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Unilateral intranigral administration of the oxidative metabolites of 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine (MPTP), 1-methyi-4-phenyl-dihydropyridine (MPDP+) or l-methyl-4-phenylpyridine (MPP+) produced dose-dependently a depletion of dopamine in the ipsilateral striatum of rats two weeks following treatment.d- Amphetamine and apomorphine induced circling toward the lesioned side in these unilaterally treated animals. No contralateral circling behavior was observed after challenging with apomorphine. This dopamine lesioning effect of MPP+ was not blocked by pretreatment of animals with a dopamine uptake blocker, GBR 12909. Furthermore, MPP+ increased the45Ca accumulation into cells at the site of injection and produced “nonspecific” cell membrane and/or cytotoxic damage seen by histological procedures. These results indicate that MPDP+ and MPP+ produced localized cytotoxic damage to nigrostriatal neurons, caused a decrease in striatal dopamine, and disrupted the nigrostriatal system's functioning following intranigral administration to rats. It is postulated that the cationic surfactant properties of MPDP+ and MPP+ might contribute to its neurotoxic effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01245141
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