Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MTX concentration in erythrocytes  (1)
  • Psoriatics  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Decrease in neutrophils observed in vivo in psoriatics after PUVA therapy (1978)
    Springer
    Archives of dermatological research 262 (1978), S. 131-134 
    Details
    ISSN: 1432-069X
    Keywords: Psoriatics ; PUVA-Neutrophils ; Leucocytes ; Psoriasis ; PUVA-Neutrophile ; Leukozyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 56 Patienten mit chronischer behandlungsresistenter Psoriasis wurden mit PUVA behandelt. Unmittelbar vor Behandlungsanfang und danach einmal wöchentlich wurde eine qualitative und quantitative Bestimmung des weißen Blutbildes vorgenommen. Die Konzentration neutrophiler Granulocyten fiel während der ersten Behandlungswoche signifikant (P〈0,01) und korrelierte wohl mit den klinischen Behandlungseffekt (P=0,02). Der Effekt der PUVA Behandlung beruht möglicherweise auf einer Reduktion der Anzahl immunokompetenter neutrophiler Granulocyten in den Psoriasis-Plaques.
    Notes: Summary In 56 patients leucocyte and differential counts were done before and at weekly intervals during PUVA treatment of chronic recalcitrant psoriasis. A statistical significant (P〈0.01) decrease in the percentage of neutrophils was observed during the first week of the PUVA therapy. This observation could be closely related to the clinical clearing of psoriasis (P=0.02). The effect of PUVA therapy in psoriasis may be due to a decrease in the number of immunocompetent neutrophils demonstrated in psoriatic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455580
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of methotrexate in erythrocytes in psoriasis (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 607-610 
    Details
    ISSN: 1432-1041
    Keywords: methotrexate ; psoriasis ; MTX concentration in erythrocytes ; intracellular accumulation ; erythrocyte folate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The intraerythrocytic levels of folate and methotrexate were measured in 25 patients on long-term methotrexate therapy for recalcitrant psoriasis. The mean steady state concentration of methotrexate in erythrocytes was 85 nmol/l and the mean erythrocyte folate concentration was 729 nmol/l. A linear correlation was not observed between these parameters, but the greatest methotrexate accumulation was found in cells at the lower end of the erythrocyte folate concentration range. In 5 patients started on methotrexate therapy the erythrocyte concentrations of methotrexate and folate were followed over 6 months. 3–4 days after the first dose, methotrexate had been accumulated against a concentration gradient in the erythrocytes. The methotrexate concentration increased steadily until the steady state level was reached after 4–6 weeks. The steady state level was maintained during the 6 month ovservation period. The erythrocyte folate concentration did not change during this period. The data suggest that methotrexate polyglutamate synthesis whithin the circulating erythrocyte is a major cause of methotrexate accumulation in these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556900
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...