ISSN:
1432-1335
Keywords:
Malignant lymphoma
;
Moloney virus
;
Thymus
;
Reticular epithelial cells
;
Thymopoietin deficiency
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Previous cytokinetic studies in Moloney-virus (M-MuLV)-induced lymphomas of BALB/c mice showed an intrathymic maturation block of prethymic lymphocytes derived from hematopoietic tissues. Thymus-cell cultures during the latent period of lymphoma development showed a proportion of nonlymphoid cells (NLC) from uninfected mice of 0.1% (3 days) to 0.002% (20 days), rising in infected mice to 1–2% after 5 weeks. Concomitantly, thymic epithelial cells exhibit progressive degenerative changes in vivo in infected mice with virus replication and in vitro a marked cellular polymorphism with nuclear atypia becomes overt. Immunofluorescence studies of thymopoietin II and serum thymus factor in epithelial cells indicate a marked decrease of these hormones in the epithelial cells from infected mice. These results suggest a functional defect of virus-infected thymic epithelial cells which causes a progressive accumulation of nondifferentiating T-cell precursors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00395395
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