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  • Mammalian embryo culture  (1)
  • embryo  (1)
  • hyperglycaemia  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Effects of β-hydroxybutyrate on rat embryos grown in culture (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 273-275 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Rat ; embryo ; embryo ; rat ; β-hydroxybutyrate ; diabetes ; maternal ; fetal malformation ; malformation ; fetal ; ketone bodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary In order to investigate further the relationship between maternal diabetes and fetal malformation, rat embryos were grown in vitro in the presence of β-hydroxybutyrate, one of the ketone bodies produced by diabetics. At 10 mM, β-hydroxybutyrate produced minor abnormalities and at 20 mM it produced major abnormalities in rat embryos.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02002633
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of glucose on rat embryos in culture (1983)
    Springer
    Diabetologia 25 (1983), S. 291-295 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Mammalian embryo culture ; diabetes ; glucose ; hyperglycaemia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To elucidate the role of hyperglycaemia in causing fetal malformation, rat embryos have been grown in vitro from the head-fold stage for 48 h in the presence of excess glucose during different parts of the culture period. Culture of rat embryos for 10 or 21 h in 55 mmol/l exogenous glucose produced abnormalities observable after 48 h in culture. When embryos cultured for 10 or 21 h in excess glucose were observed by scanning electron microscopy at the end of the glucose treatment, abnormalities could be observed which may indicate how later malformations are formed. Thus it is possible that a relatively brief hyperglycaemic episode at a critical stage of embryogenesis may endanger the fetus of a diabetic mother.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00279946
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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