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  • 1
    Electronic Resource
    Electronic Resource
    Induction of tumors in the small intestine and mammary gland of female Donryu rats by continuous oral administration of N-carboxymethyl-N-nitrosourea (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 12-16 
    Details
    ISSN: 1432-1335
    Keywords: N-Carboxymethyl-N-nitrosourea (CMNU) ; Female Donryu rats ; Intestinal tumor ; Mammary tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The carcinogenicity of N-carboxymethyl-N-nitrosourea (CMNU), a naturally occurring N-nitroso compound, was tested in female Donryu rats. Four groups of female Donryu rats were given 400, 200, 100, or 0 ppm of CMNU solution continuously as drinking water. The incidence of tumors was highest and the mean survival time shortest in the 400 ppm group. A dose-effect relationship was observed in the tumor incidence and the mean survival time and the incidences of tumors in all experimental groups were significantly different from those in the control group. In the 400 ppm group, tumors were detected most frequently in the small intestine, followed by the mammary gland. In contrast, most tumors were observed in the mammary gland in the other two experimental groups, although dose-dependent induction of tumors of the small intestine was also detected in these two groups. The organ specificity of CMNU is compared with that of other N-alkyl-N-nitrosourea derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399891
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  • 2
    Electronic Resource
    Electronic Resource
    Extraovarian peritoneal serous papillary carcinoma showing complete remission after treatment with cisplatin (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 337-340 
    Details
    ISSN: 1437-7772
    Keywords: Key words Extraovarian peritoneal serous papillary carcinoma ; Peritoneum ; Müllerian potential ; Cisplatin ; CA125 ; CA15-3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extraovarian peritoneal serous papillary carcinoma is a rare disease in women that arises from extraovarian peritoneum with müllerian potential. It shows histopathological findings identical to those of ovarian serous carcinoma. At diagnosis, this disease usually exhibits peritoneal carcinomatosis, but evidence of a primary site is lacking. We experienced a case of extraovarian peritoneal serous papillary carcinoma in a 72-year-old woman who complained of abdominal distension and soon after developed bowel obstruction. Although we failed to perform any effective surgical procedure at laparotomy, because the cancer was extremely advanced, treatment with cisplatin resulted in rapid reduction of the tumor, and, finally, in its complete disappearance. Cisplatin was administered only three times, and the total dose was 300 mg. The patient is still alive and clinically free of recurrence 32 months after her first visit to our hospital. In this report we describe her clinical course, and discuss the diagnosis and treatment of this disease, and the usefulness of tumor markers for monitoring it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012060
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  • 3
    Electronic Resource
    Electronic Resource
    Mammary tumorigenic effect of a new nitrosourea, 1,3-dibutyl-l-nitrosourea (B-BNU), in female Donryu rats (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 35-41 
    Details
    ISSN: 1432-1335
    Keywords: Mammary tumor ; Nitrosourea ; 1,3-Dibutyl-l-nitrosourea ; Donryu rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four groups (groups 1-4) of female Donryu rats were given continuously 400, 200, 100, or 0 ppm solution of 1,3-dibutyl-1-nitrosourea (B-BNU) as their drinking water, and were studied for the development of tumors. The incidence of mammary tumors was 15/19 (79%), 20/24 (83%), 21/26 (81%), and 8/25 (32%) in groups 1, 2, 3, and 4, respectively. In addition, hematopoietic neoplasms, uterine tumors, and vaginal tumors developed in 13, 11, and six rats, respectively in 69 treated rats. Other tumors were infrequent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412895
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  • 4
    Electronic Resource
    Electronic Resource
    Organ-specific carcinogenicity of N-methyl-N-nitrosourea in F344 and ACI/N rats (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 178-182 
    Details
    ISSN: 1432-1335
    Keywords: N-Methyl-N-nitrosourea (MNU) ; F344/DuCrj rat ; ACI/N rat ; Neurogenic tumor ; Organspecific carcinogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male and female F344 rats were continuously administered N-methyl-N-nitrosourea (MNU) in their drinking water at concentrations of 200 or 100 ppm, and both sexes of ACI/N rats were given MNU at a concentration of 200 ppm. By the 42nd week of the experiment, high incidences of brain/spinal cord tumors were observed in both strains of rats. Histologically, many of them were astrocytomas or anaplastic astrocytomas. In addition, malignant neurinomas were also detected in the spinal nerve roots and trigeminal nerves, although their incidences were rather low. There was no difference in the type and incidence of these neurogenic tumors between the two strains of rats. Tumors of the tongue and esophagus were mainly observed in the high-dose group of F344 rats and those of the glandular stomach were observed in the low-dose group of F344 rats. In ACI/N rats, tumors of the heart and renal pelvis were detected. The organ-specific carcinogenicity of MNU in these two strains of rats was compared with that of MNU in Donryu rats. It was demonstrated that organ specificity of MNU given orally was influenced not only by the strain of rats but also by the dose level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390353
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  • 5
    Electronic Resource
    Electronic Resource
    Carcinogenicity and organ specificity of N-trimethylsilylmethyl-N-nitrosourea (TMS-MNU), N-neopentyl-N-nitrosourea (neoPNU), and N-methyl-N-nitrosourea (MNU) in rats (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 473-476 
    Details
    ISSN: 1432-1335
    Keywords: Organ specificity ; N-Trimethylsilylmethyl-N-nitrosourea (TMS-MNU) ; N-Neopentyl-N-nitrosourea (neoPNU) ; N-Methyl-N-nitrosourea (MNU) ; F344 rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The carcinogenicity and organ specificity of TMS-MNU and neoPNU, a carbon-analogue of TMS-MNU, in rats were investigated and compared with those of MNU. Compounds were dissolved in olive oil and rats in the experimental groups received 20 weekly intragastric intubations of 10 mg/kg of MNU or equimolar amounts of TMS-MNU or neoPNU in the same manner. The experiment was terminated when the survivors were sacrificed at the 52nd week after the final adminstration. In the TMS-MNU and MNU groups, tumors of the forestomach were induced and the incidence was 100% in the groups of both sexes. In addition, tumors of the glandular stomach, nervous system, kidney, and lung were also observed in these groups. Neurogenic tumors were found more frequently in the MNU group than in the TMS-MNU group. The incidence of lung tumors, however, was higher in the TMS-MNU group than in the MNU group. On the other hand, in the control and neoPNU groups, no tumor was found in these organs except the lung, and all tumors observed in these two groups were histologically similar to spontaneous ones in this strain of rats. These results indicate that the carcinogenicity of N-alkyl-N-nitrosoureas is dependent on the chemical structure of their alkyl chain. The result of the present study coincides with the previous result that the species of TMS-MNU in the alkylating step is the same as that of MNU, but different from neoPNU. The difference in the organ specificity between TMS-MNU and MNU demonstrates that the organ specificity is dominantly dependent on the distribution of the chemicals, since TMS-MNU may possibly be distributed differently from MNU because of its different partition property.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391494
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