ISSN:
1439-6327
Keywords:
Verapamil
;
Maximal exercise
;
Side-effect
;
Metabolism
;
Heart rate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a double-blind cross-over study, the effects of verapamil on the cardiovascular and metabolic changes during a progressive maximal exercise test were studied in 12 healthy volunteers. Each subject was treated with placebo and verapamil in 3 different dosages: 3×40, 3×80 and 3×120 mg · d−1 in random order. Drugs were administered for 2 days; on the 3rd day, 2 h after the last dose, a progressive exercise test until exhaustion was performed on a bicycle ergometer. No significant differences in maximal exercise capacity were found between the 4 groups of medication. $$\dot V_{{\text{O}}_{\text{2}} }$$ , $$\dot V_{CO_2 }$$ , and $$\dot V_E $$ were also unaffected by verapamil administration. Heart rate during exercise was reduced dose-dependently (p〈0.001). With the highest dose of verapamil, maximal heart rate was reduced by 13±1 beats · min−1. No effect could be shown on parameters of carbohydrate and fat metabolism. Perceived exertion, estimated by the Borg scale, did not differ between placebo and the 3 medication groups. The study shows that despite a distinct reduction of heart rate, maximal exercise capacity remains unaffected after verapamil use.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421644
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