ISSN:
1432-069X
Keywords:
5-S-Cysteinyldopa
;
Fluorescence method (Falck and Hillarp)
;
Melanoma, amelanotic
;
Basal cell epithelioma
;
Pigmented nevus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Histochemical findings of primary and metastatic amelanotic melanomas were shown by the formaldehyde-induced fluorescence method (Falck and Hillarp). All or some of the amelanotic melanoma cells were discovered to emit green specific fluorescence. Results of the determination of 5-S-cysteinyldopa and DOPA in amelanotic melanoma tissues indicated that the specific fluorescence emitted by these cells is primarily due to the presence of 5-S-cysteinyldopa. The values of 5-S-cysteinyldopa in these tissues were lower than those in melanotic melanoma, but were approximately the same as those in pigmented nevus. When unpigmented tumors were histopathologically revealed to be malignant, amelanotic melanoma could be definitely diagnosed by the fluorescence method of Falck and Hillarp and the biochemical analysis of 5-S-cysteinyldopa in the tissues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417207
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